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Greek anatomist herophilus: the father of anatomy

Bay NS, Bay BH

One of the most stirring controversies in the history of Anatomy is that Herophilus, an ancient Greek anatomist and his younger contemporary, Erasistratus, were accused of performing vivisections of living...
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Control of neuronal migration through rostral migration stream in mice

Sun W, Kim H, Moon Y

During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located...
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Expression of ErbB4 in the apoptotic neurons of Alzheimer's disease brain

Woo RS, Lee JH, Yu HN, Song DY, Baik TK

Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain,...
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Mega-dose vitamin C attenuated lung inflammation in mouse asthma model

Jeong YJ, Kim JH, Kang JS, Lee WJ, Hwang YI

Asthma is a Th2-dependent disease mediated by IgE and Th2 cytokines, and asthmatic patients suffer from oxidative stresses from abnormal airway inflammation. Vitamin C is a micro-nutrient functioning as an...
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Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells

Kim BG, Kwak HB, Choi EY, Kim HS, Kim MH, Kim SH, Choi MK, Chun CH, Oh J, Kim JJ

Among the several rotenoids, amorphigenin is isolated from the leaves of Amopha Fruticosa and it is known that has anti-proliferative effects and anti-cnacer effects in many cell types. The main...
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Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction

Choi YH, Chai OH, Han EH, Choi SY, Kim HT, Song CH

Alpha-lipoic acid (LA), a naturally occurring dithiol compound, is an essential cofactor in metabolic reactions involved in energy utilization. LA improves glycemic control, reduces diabetic polyneuropathies, atherosclerosis, and allergic inflammation....
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Ultrastructural analysis of low-threshold mechanoreceptive vibrissa afferent boutons in the cat trigeminal caudal nucleus

Paik SK, Choi SK, Lee JW, Kim TH, Ahn DK, Yoshida A, Kim YS, Bae YC

Ultrastructural parameters related to synaptic release and their correlation with synaptic connectivity were analyzed in the low-threshold mechanoreceptive vibrissa afferent boutons in laminae III and IV of the trigeminal caudal...
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Direct protection of cultured neurons from ischemia-like injury by minocycline

Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, Yenari MA

Minocycline, a tetracycline antibiotic, is now known to protect cells via an anti-inflammatory mechanism. We further explored this effect using an in vitro model of ischemia-like injury to neurons. Coculturing...
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Downregulation of NFAT2 promotes melanogenesis in B16 melanoma cells

Lee YS, Kim DW, Kim S, Choi HI, Lee Y, Kim CD, Lee JH, Lee SD, Lee YH

Nuclear factor of activated T-cells (NFAT) proteins are, calcium-regulated transcription factors, key regulator of stimulation-dependent gene activation. In our microarray analysis for the genes expressed in human black and white...
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HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression

Kim SD, Park RY, Kim YR, Kim IJ, Kang TW, Nam KI, Ahn KY, Bae CS, Kim BY, Park SS, Jung C

During the prostate cancer (PCa) development and its progression into hormone independency, androgen receptor (AR) signals play a central role by triggering the regulation of target genes, including prostate-specific antigen....
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