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Changes in Bone Metabolism in Young Castrated Male Rats

Ryu SJ, Ryu DS, Kim JY, Park JY, Kim KH, Chin DK, Kim KS, Cho YE, Kuh SU

PURPOSE: To determine the window of time during which osteoporosis affects the management of spinal surgery and the mechanism of bone metabolism changes in males with osteoporosis by examining changes...
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The incidence and histological characteristics of intratubular germ cell neoplasia in postpubertal cryptorchid testis

Ryang SH, Jung JH, Eom M, Song JM, Chung HC, Chae Y, Lee CM, Kim KJ

PURPOSE: It is well known that testicular germ cell tumors arise with increased frequency in patients with cryptorchidism. In addition, intratubular germ cell neoplasia (ITGCN) is a precursor lesion to...
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Stimulating Effect of a Novel Synthesized Sulfonamido-Based Gallate ZXHA-TC on Primary Osteoblasts

Jin P, Liao L, Lin X, Guo Q, Lin C, Wu H, Zheng L, Zhao J

PURPOSE: This study is intended to investigate the effects of plants or plant-derived antioxidants on prevention of osteoporosis through the maintenance of reactive oxygen species (ROS) at a favorable level. MATERIALS...
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Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions

Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW

  • KMID: 2154225
  • Exp Mol Med.
  • 2013 Jan;45(1):e6.
Many studies have reported that an electromagnetic field can promote osteogenic differentiation of mesenchymal stem cells. However, experimental results have differed depending on the experimental and environmental conditions. Optimization of...
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Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton's jelly for treating bone defects

Kang BJ, Ryu HH, Park SS, Koyama Y, Kikuchi M, Woo HM, Kim WH, Kweon OK

Alternative sources of mesenchymal stem cells (MSCs) for replacing bone marrow (BM) have been extensively investigated in the field of bone tissue engineering. The purpose of this study was to...
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Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration

Yang HS, La WG, Cho YM, Shin W, Yeo GD, Kim BS

  • KMID: 1383796
  • Exp Mol Med.
  • 2012 May;44(5):350-355.
Bone morphogenetic protein-2 (BMP-2) is used to promote bone regeneration. However, the bone regeneration ability of BMP-2 relies heavily on the delivery vehicle. Previously, we have developed heparin-conjugated fibrin (HCF),...
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Individual Variation in Growth Factor Concentrations in Platelet-rich Plasma and Its Influence on Human Mesenchymal Stem Cells

Cho HS, Song IH, Park SY, Sung MC, Ahn MW, Song KE

BACKGROUND: The objective of this study was to explore whether individual variations in the concentration of growth factors (GFs) influence the biologic effects of platelet-rich plasma (PRP) on human mesenchymal...
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Bone Morphogenetic Protein Receptor in the Osteogenic Differentiation of Rat Bone Marrow Stromal Cells

Wang A, Ding X, Sheng S, Yao Z

PURPOSE: Several signaling pathways have been shown to regulate the lineage commitment and terminal differentiation of bone marrow stromal cells (BMSCs). Bone morphogenetic protein (BMP) signaling has important effects on...
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Na+-Ca2+ exchanger modulates Ca2+ content in intracellular Ca2+ stores in rat osteoblasts

Jung SY, Park YJ, Park YJ, Cha SH, Lee MZ, Suh CK

  • KMID: 756068
  • Exp Mol Med.
  • 2007 Aug;39(4):458-468.
Na+ -Ca2+ exchanger (NCX) transports Ca2+ coupled with Na+ across the plasma membrane in a bi-directional mode. Ca2+ flux via NCX mediates osteogenic processes, such as formation of extracellular matrix...
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Macrophage Activation Syndrome in a Child with Systemic Juvenile Rheumatoid Arthritis

Hur M, Kim YC, Lee KM, Kim KN

Macrophage activation syndrome (MAS) is a rare and potentially fatal complication of rheumatic disorders in children. We describe a 13-month-old boy in whom MAS developed as a complication of systemic...
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The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells

Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM, Lee EJ, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK

Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of...
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Interaction of Mesenchymal Stem Cells and Osteoblasts for in vitro Osteogenesis

Kim H, Lee JH, Suh H

It has recently been reported that bone marrow-derived mesenchymal stem cells (MSCs), which are systemically administrated to different species, undergo site-specific differentiation. This suggests that the tissue specific cells may...
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Effect of Centrifugal Force on Cellular Activity of Osteoblastic MC3T3-E1 Cells in vitro

Lee DH, Park JC, Suh H

The effects of centrifugal force on growth and differentiation of osteoblastic cells cultured in alpha-MEM containing 1% Fetal bovine serum were investigated by assays of DNA synthesis, alkaline phosphatase activity...
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Interaction of TGF-beta1 and rhBMP-2 on Human Bone Marrow Stromal Cells Cultured in Collagen Gel Matrix

Kim MK, Niyibizi C

Transforming growth factor-beta1 (TGF-beta1) and bone morphogenetic protein-2 (BMP-2) are abundant proteins in the bone matrix. However, their interaction in controlling osteoblast differentiation is not clearly understood. In this study,...
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