- The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
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Choi E, Kim Y, Kim K
- KMID: 1715873
- Yonsei Med J.
- 2006 Feb;47(1):55-62.
- doi: 10.3349/ymj.2006.47.1.55
The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Evaluation of a Multiplex Real-time PCR Assay for the Detection of Respiratory Viruses in Clinical Specimens
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Rheem I, Park J, Kim TH, Kim JW
- KMID: 2434480
- Ann Lab Med.
- 2012 Nov;32(6):399-406.
BACKGROUND: In this study, we evaluated the analytical performance and clinical potential of a one-step multiplex real-time PCR assay for the simultaneous detection of 14 types of respiratory viruses using... -
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- Enhancing mucosal immunity in mice by recombinant adenovirus expressing major epitopes of porcine circovirus-2 capsid protein delivered with cytosine-phosphate-guanosine oligodeoxynucleotides
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Chang HT, He XY, Liu YF, Chen L, Guo QH, Yu QY, Zhao J, Wang XW, Yang X, Wang CQ
- KMID: 2155623
- J Vet Sci.
- 2014 Sep;15(3):399-407.
- doi: 10.4142/jvs.2014.15.3.399
A recombinant replication-defective adenovirus expressing the major epitopes of porcine circovirus-2 (PCV-2) capsid protein (rAd/Cap/518) was previously constructed and shown to induce mucosal immunity in mice following intranasal delivery. In... -
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- Improved development of somatic cell cloned bovine embryos by a mammary gland epithelia cells in vitro model
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He XY, Ma LB, He XN, Si WT, Zheng YM
- KMID: 2413163
- J Vet Sci.
- 2016 Jun;17(2):145-152.
- doi: 10.4142/jvs.2016.17.2.145
Previous studies have established a bovine mammary gland epithelia cells in vitro model by the adenovirus-mediated telomerase (hTERT-bMGEs). The present study was conducted to confirm whether hTERT-bMGEs were effective target... -
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- Gene Therapy Using Hepatocyte Growth Factor Expressing Adenovirus Improves Skin Flap Survival in a Rat Model
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Rah DK, Yun IS, Yun CO, Lee SB, Lee WJ
- KMID: 2151418
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S228-S236.
- doi: 10.3346/jkms.2014.29.S3.S228
Hepatocyte growth factor (HGF) is a potent angiogenic factor that can stimulate the production of blood vessels in ischemic tissue. We investigated whether gene therapy using HGF-expressing adenovirus could enhance... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- Identification of Adenovirus, Influenza Virus, Parainfluenza Virus, and Respiratory Syncytial Virus by Two Kinds of Multiplex Polymerase Chain Reaction (PCR) and a Shell Vial Culture in Pediatric Patients with Viral Pneumonia
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Lee JH, Chun JK, Kim DS, Park Y, Choi JR, Kim HS
- KMID: 1071430
- Yonsei Med J.
- 2010 Sep;51(5):761-767.
- doi: 10.3349/ymj.2010.51.5.761
PURPOSE: Early identification of causative agents in lower respiratory infection of pediatric patients can reduce morbidity and prevent an overuse of antimicrobials. Two kinds of multiplex polymerase chain reaction (PCR)... -
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- Respiratory Viral Infections after Hematopoietic Stem Cell Transplantation in Children
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Choi JH, Choi EH, Kang HJ, Park KD, Park SS, Shin HY, Lee HJ, Ahn HS
- KMID: 2157998
- J Korean Med Sci.
- 2013 Jan;28(1):36-41.
- doi: 10.3346/jkms.2013.28.1.36
This study was performed to characterize respiratory viral infections in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Study samples included 402 respiratory specimens obtained from 358 clinical episodes that... -
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- Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy
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Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG
- KMID: 1123370
- Exp Mol Med.
- 2011 Oct;43(10):580-586.
- doi: 10.3858/emm.2011.43.10.065
Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients... -
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- Gene transfer using liposome-complexed adenovirus seems to overcome limitations due to coxsackievirus and adenovirus receptor-deficiency of cancer cells, both in vitro and in vivo
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Han SY, Lee YJ, Jung HI, Lee SW, Lim SJ, Hong SH, Jeong JS
- KMID: 1094122
- Exp Mol Med.
- 2008 Aug;40(4):427-434.
- doi: 10.3858/emm.2008.40.4.427
Use of adenoviruses as vehicle for gene therapy requires that target cells express appropriate receptors such as coxsakievirus and adenovirus receptor (CAR). We show here that CAR-deficiency in cancer cells,... -
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- Orphan nuclear receptor small heterodimer partner inhibits angiotensin II-stimulated PAI-1 expression in vascular smooth muscle cells
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Lee KM, Seo HY, Kim MK, Min AK, Ryu SY, Kim YN, Park YJ, Choi HS, Lee KU, Park WJ, Park KG, Lee IK
- KMID: 946666
- Exp Mol Med.
- 2010 Jan;42(1):21-29.
- doi: 10.3858/emm.2010.42.1.002
Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the... -
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- Polarization of protective immunity induced by replication-incompetent adenovirus expressing glycoproteins of pseudorabies virus
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Han YW, Aleyas AG, George JA, Kim SJ, Kim HK, Yoon HA, Yoo DJ, Kang SH, Kim K, Eo SK
- KMID: 1072939
- Exp Mol Med.
- 2008 Dec;40(6):583-595.
- doi: 10.3858/emm.2008.40.6.583
Replication-incompetent adenoviruses expressing three major glycoproteins (gB, gC, and gD) of pseudorabies virus (PrV) were constructed and used to examine the ability of these glycoproteins to induce protective immunity against... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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- Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells
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Kong G, Lee S, Kim KS
- KMID: 648350
- J Korean Med Sci.
- 2001 Dec;16(6):712-718.
- doi: 10.3346/jkms.2001.16.6.712
In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase... -
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- Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
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Park S, Kim HT, Yun S, Kim IS, Lee J, Lee IS, Park KI
- KMID: 1058023
- Exp Mol Med.
- 2009 Jul;41(7):487-500.
- doi: 10.3858/emm.2009.41.7.054
Neural progenitor cells (NPs) have shown several promising benefits for the treatment of neurological disorders. To evaluate the therapeutic potential of human neural progenitor cells (hNPs) in amyotrophic lateral sclerosis... -
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- Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines
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Choi SH, Shin HW, Park JY, Yoo JY, Kim DY, Ro WS, Yun CO, Han KH
- KMID: 1717322
- Korean J Hepatol.
- 2010 Sep;16(3):280-287.
- doi: 10.3350/kjhep.2010.16.3.280
BACKGROUND/AIMS: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of... -
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- Evaluation of an Immunochromatographic Assay for the Rapid and Simultaneous Detection of Rotavirus and Adenovirus in Stool Samples
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Kim J, Kim HS, Kim HS, Kim JS, Song W, Lee KM, Lee S, Park KU, Lee W, Hong YJ
- KMID: 1791923
- Ann Lab Med.
- 2014 May;34(3):216-222.
- doi: 10.3343/alm.2014.34.3.216
BACKGROUND: We evaluated the analytical and clinical performances of the SD BIOLINE Rota/Adeno Rapid kit (SD Rota/Adeno Rapid; Standard Diagnostics, Inc., Korea), an immunochromatographic assay (ICA), for the simultaneous detection... -
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