- Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells
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Lee DH, Lee CS
- KMID: 1512942
- Korean J Physiol Pharmacol.
- 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of... -
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- Role of Casein Kinase 2 in Parkinsonian Toxin 1-Methyl-4-phenylpyridinium-induced Cell Death
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Lee SY, Hwang JY, Han JH, Kim DE, Lee CS
- KMID: 2184974
- J Korean Neurol Assoc.
- 2010 Aug;28(3):157-165.
BACKGROUND: Protein casein kinase 2 is involved in signal transduction, cell growth, and apoptosis. However, it has not been elucidated whether parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal cell death is mediated... -
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- Monoamine Oxidase Inhibitors Attenuate Cytotoxicity of 1-Methyl-4-phenylpyridinium by Suppressing Mitochondrial Permeability Transition
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Lee CS
- KMID: 1587399
- Korean J Physiol Pharmacol.
- 2006 Aug;10(4):207-212.
Mitochondrial permeability transition has been shown to be involved in neuronal cell death. Mitochondrial monoamine oxidase (MAO)-B is considered to play a part in the progress of nigrostriatal cell death.... -
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- Inhibitory Effect of 3,4,5-Tricaffeoylquinic Acid on Parkinsonian Toxin 1-Methyl-4-phenylpyridinium-induced Apoptosis
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Joo JJ, Kang JH, Han JH, Kim DE, Lee CS
- KMID: 2191157
- J Korean Neurol Assoc.
- 2014 May;32(2):72-81.
BACKGROUND: 1-Methyl-4-phenylpyridinium (MPP+) causes a neuronal cell injury that is similar to the findings observed in Parkinson's disease. Caffeoylquinic acid derivatives have demonstrated anti-oxidant and anti-inflammatory effects. Nevertheless, the effect... -
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- Protective Effects of Epigallocatechin-3-gallate against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Noh HG, Jang S, Park SJ, Kim SH, Jeong HS, Park JS
- KMID: 2274899
- Chonnam Med J.
- 2007 Aug;43(2):73-79.
1-methyl-4-phenylpyridinium (MPP+) is a neurotoxin that selectively inhibits the mitochondrial functions of dopaminergic neurons in the substantia nigra pars compacta. MPP+ administration is accepted as in vivo and in vitro... -
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- Inhibitory Effect of Rotundarpene on Parkinsonian Neurotoxin 1-Methyl-4-Phenylpyridinium-Induced Apoptotic Cell Death
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Han SW, Lee CS, Hwang IH, Han JH, Kim DE
- KMID: 2359443
- J Korean Neurol Assoc.
- 2016 Nov;34(5):324-332.
- doi: 10.17340/jkna.2016.4.6
BACKGROUND: The extract and hemiterpene glycosides of Ilex Rotunda Thunb exert antioxidant and anti-inflammatory effects. The effect of rotundarpene on apoptosis in neuronal cells caused by the 1-methyl-4-phenylpyridinium (MPPâº) has... -
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- Protective Effects of K6PC-5, A Sphingosine Kinase Activator, Against 1-methyl-4-phenylpyridinium-induced Dopaminergic Neuronal Cell Death
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Jang S, Choi SS, Kim SH, Park JS, Jeong HS
- KMID: 2172296
- Chonnam Med J.
- 2008 Dec;44(3):162-168.
- doi: 10.4068/cmj.2008.44.3.162
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metaolite, regulates multiple cellular responses such as Ca2+ signaling, cellular growth and survival, and differentiation. Sphingosine kinase (SphK) is a key enzyme in modulating the... -
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- Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells
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Kim YJ, Lee CS
- KMID: 1486145
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):65-71.
- doi: 10.4196/kjpp.2008.12.2.65
The present study examined the inhibitory effect of licorice compounds glycyrrhizin and a metabolite 18 beta-lycyrrhetinic acid on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse and on the 1-methyl-4-phenylpyridinium... -
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- Glucose Levels in Culture Medium Determine Cell Death Mode in MPP+-treated Dopaminergic Neuronal Cells
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Yoon SY, Oh YJ
- KMID: 2165555
- Exp Neurobiol.
- 2015 Sep;24(3):197-205.
- doi: 10.5607/en.2015.24.3.197
We previously demonstrated that 1-methyl-4-phenylpyridinium (MPP+) causes caspase-independent, non-apoptotic death of dopaminergic (DA) neuronal cells. Here, we specifically examined whether change of glucose concentration in culture medium may play a... -
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- Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells
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Kim HJ, Kim J, Kang KS, Lee KT, Yang HO
- KMID: 2170619
- Biomol Ther.
- 2014 Jul;22(4):275-281.
Autophagy is a series of catabolic process mediating the bulk degradation of intracellular proteins and organelles through formation of a double-membrane vesicle, known as an autophagosome, and fusing with lysosome.... -
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- Inhibition of Oxidative Tissue Damage and Mitochondrial Dysfunction by Glycyrrhizin in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease
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Park SE, Hong KM, Han JH, Kim DE, Lee CS
- KMID: 2343255
- J Korean Neurol Assoc.
- 2007 Aug;25(3):353-363.
BACKGROUND: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces an irreversible and severe parkinsonian-like syndrome. A licorice compound glycyrrhizin exerts a cytoprotective or anti-oxidant effect in various disease conditions, but its effect against the MPTP-induced... -
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- Functional Role of Parkin against Oxidative Stress in Neural Cells
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Hwang M, Lee JM, Kim Y, Geum D
- KMID: 2169353
- Endocrinol Metab.
- 2014 Mar;29(1):62-69.
- doi: 10.3803/EnM.2014.29.1.62
BACKGROUND: Parkinson disease (PD) is caused by selective cell death of dopaminergic neurons in the substantia nigra. An early onset form of PD, autosomal recessive juvenile parkinsonism has been associated... -
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- MiR-212 Attenuates MPP+-Induced Neuronal Damage by Targeting KLF4 in SH-SY5Y Cells
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Song Y, Liu Y, Chen X
- KMID: 2407865
- Yonsei Med J.
- 2018 May;59(3):416-424.
- doi: 10.3349/ymj.2018.59.3.416
PURPOSE: Parkinson's disease (PD) is a common age-dependent neurodegenerative disease. MiR-212 has been demonstrated to exert protective effects in several neurological disorders. The present study aimed to investigate the role... -
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