- Nuclear protein binding patterns in the 5'-upstream regulatory elements of HLA class I genes
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Park JH, Kim JD, Kim SJ
- KMID: 1728914
- Yonsei Med J.
- 1994 Sep;35(3):295-307.
- doi: 10.3349/ymj.1994.35.3.295
The expression of MHC class I genes has been thought to be regulated by two major cis-acting regulatory elements. The first region, enhancer A (Enh A) spanning from positions -210... -
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- Chromosomal Losses are Associated with Hypomethylation of the Gene-Control Regions in the Stomach with a Low Number of Active Genes
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Jung YC, Hong SJ, Kim YH, Kim SJ, Kang SJ, Choi SW, Rhyu MG
- KMID: 1107535
- J Korean Med Sci.
- 2008 Dec;23(6):1068-1089.
- doi: 10.3346/jkms.2008.23.6.1068
Transitional-CpG methylation between unmethylated promoters and nearby methylated retroelements plays a role in the establishment of tissue-specific transcription. This study examined whether chromosomal losses reducing the active genes in cancers... -
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- Cancer Metastasis and Metastasis Suppressors
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Song IH
- KMID: 1111502
- Korean J Gastroenterol.
- 2004 Jan;43(1):1-7.
Cancer metastasis, a complex and sequential network of cellular events involved in the migration and establishment of malignant cells from original site to distant foci, is an important and significant... -
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- Epstein-Barr virus latent genes
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Kang MS, Kieff E
- KMID: 2155396
- Exp Mol Med.
- 2015 Jan;47(1):e131.
- doi: 10.1038/emm.2014.84
Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited... -
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- Polymorphisms in Apoptosis-Related Genes and TP53 Mutations in Non-Small Cell Lung Cancer
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Bae EY, Lee EJ, Kang HG, Lee SY, Jin G, Lee WK, Choi JE, Jeon HS, Lim JO, Lee EB, Park JY
- KMID: 1123458
- J Korean Med Sci.
- 2011 Nov;26(11):1527-1530.
- doi: 10.3346/jkms.2011.26.11.1527
Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby... -
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- Immunoglobulin and T-cell receptor gene rearrangement analysis in malignant lymphoid neoplasms
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Park CK, Kim CW, Kim IS, Lee JD
- KMID: 644822
- J Korean Med Sci.
- 1994 Oct;9(5):362-368.
- doi: 10.3346/jkms.1994.9.5.362
Gene rearrangement analysis using Southern-blot hybridization technique is a standard method for evaluating clonal receptor gene rearrangement. Both clonality and lineage can be identified in lymphoid neoplasms by the demonstration... -
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- Germline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
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Zhao Q, Yang J, Li L, Cao D, Yu M, Shen K, the BGI Group
- KMID: 2413427
- J Gynecol Oncol.
- 2017 Jul;28(4):e39.
- doi: 10.3802/jgo.2017.28.e39
OBJECTIVE: To define genetic profiling of homologous recombination (HR) deficiency in Chinese ovarian cancer patients. METHODS: we have applied next-generation sequencing to detect deleterious mutations through all exons in 31 core... -
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- Expressions of c-fos and c-myc genes during 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)-induced rat hepatocarcinoma
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Chai KJ, Kim JS, Lee HK
- KMID: 1120235
- Yonsei Med J.
- 1992 Sep;33(3):240-248.
- doi: 10.3349/ymj.1992.33.3.240
We investigated the expression of the growth-related nuclear proto-oncogenes, c-fos and c-myc, in early preneoplastic regions and tumor nodules of 3'-MeDAB induced rat hepatocarcinoma. To amplify the levels of these... -
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- Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas
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Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Hong SI, Choi KS
- KMID: 927177
- J Korean Med Sci.
- 1995 Dec;10(6):442-448.
- doi: 10.3346/jkms.1995.10.6.442
Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect... -
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- Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia
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Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T
- KMID: 1781831
- J Korean Med Sci.
- 2006 Apr;21(2):253-258.
- doi: 10.3346/jkms.2006.21.2.253
The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression... -
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- Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma
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Choi SW, Lee TW, Yang SW, Hong WS, Kim CM, Lee JO
- KMID: 1421955
- J Korean Med Sci.
- 1993 Feb;8(1):73-77.
- doi: 10.3346/jkms.1993.8.1.73
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79,... -
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- Autosomal Recessive Multiple Epiphyseal Dysplasia in a Korean Girl Caused by Novel Compound Heterozygous Mutations in the DTDST (SLC26A2) Gene
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Cho TJ, Kim OH, Lee HR, Shin SJ, Yoo WJ, Park WY, Park SS, Cho SI, Choi IH
- KMID: 1792968
- J Korean Med Sci.
- 2010 Jul;25(7):1105-1108.
- doi: 10.3346/jkms.2010.25.7.1105
Multiple epiphyseal dysplasia is caused by heterogenous genotypes involving more than six genes. Recessive mutations in the DTDST gene cause a phenotype of recessive multiple epiphyseal dysplasia (rMED). The authors... -
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- Deletions of 9p21 and TP53 in bladder cancer
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Park WS, Oh MJ, Lee HK, Lee KO, Rhyu MG, Dong SM, Lee JY, Kim SH
- KMID: 644955
- J Korean Med Sci.
- 1996 Jun;11(3):233-238.
- doi: 10.3346/jkms.1996.11.3.233
The objective of this study was to characterize the alterations of 9p21 and TP53 in Korean transitional bladder cancer and to assess the relationship between the histopathologic parameter and the... -
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- Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas
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Nam DH, Song SY, Park KS, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH
- KMID: 938873
- Exp Mol Med.
- 2001 Sep;33(3):111-116.
Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11... -
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- Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers
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Kim KH, Kim YS
- KMID: 1066882
- Yonsei Med J.
- 1995 Aug;36(4):322-331.
- doi: 10.3349/ymj.1995.36.4.322
To determine whether the dysfunction of p53 caused either by mutation of the p53 gene itself or by binding to E6 protein of oncogenic HPVs is involved in the transitional... -
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- Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma
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Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US
- KMID: 1785699
- J Korean Med Sci.
- 2004 Feb;19(1):83-86.
- doi: 10.3346/jkms.2004.19.1.83
Hepatocellular carcinomas (HCCs) show genomic alterations, including DNA rearrangements associated with HBV DNA integration, loss of heterozygosity, and chromosomal amplification. The genes most frequently involved are those encoding tumor suppressors.... -
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- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- Associations of Moyamoya Patients with HLA Class I and Class II Alleles in the Korean Population
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Han H, Pyo CW, Yoo DS, Huh PW, Cho KS, Kim DS
- KMID: 1086747
- J Korean Med Sci.
- 2003 Dec;18(6):876-880.
- doi: 10.3346/jkms.2003.18.6.876
Moyamoya disease is characterized by progressive cerebrovascular occlusion at the peripheral internal carotid artery and development of abnormal collateral circulation at the cerebral basal region. Although abnormal thrombogenesis, inflammation and... -
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- Expression of Vascular Endothelial Growth Factor and p53 in Pancreatic Carcinomas
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Joo YE, Sohn YH, Lee WS, Park CH, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 759604
- Korean J Intern Med.
- 2002 Sep;17(3):153-159.
BACKGROUND: Angiogenesis has been shown to be a critical aspect of tumor growth and progression. Vascular endothelial growth factor (VEGF) has potent angiogenic activity and has been identified in... -
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- Identification of Tumor Suppressor Loci on the Long Arm of Chromosome 4 in Primary Small Cell Lung Cancers
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Cho ES, Chang J, Chung KY, Shin DH, Kim YS, Kim SK, Kim SK
- KMID: 1118962
- Yonsei Med J.
- 2002 Apr;43(2):145-151.
- doi: 10.3349/ymj.2002.43.2.145
Recent cytogenetic studies have indicated that loss of the long arm of chromosome 4 is a frequent event in small cell lung cancer (SCLC), which suggests the presence of tumor... -
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