J Korean Med Sci.  2003 Dec;18(6):876-880. 10.3346/jkms.2003.18.6.876.

Associations of Moyamoya Patients with HLA Class I and Class II Alleles in the Korean Population

• Han H
• Pyo CW
• Yoo DS
• Huh PW
• Cho KS
• Kim DS

• KMID: 1086747
• DOI: http://doi.org/10.3346/jkms.2003.18.6.876

Abstract

Moyamoya disease is characterized by progressive cerebrovascular occlusion at the peripheral internal carotid artery and development of abnormal collateral circulation at the cerebral basal region. Although abnormal thrombogenesis, inflammation and autoimmune process might be involved in the etiology, the genetic pathogenesis of Moyamoya disease is still unknown. To evaluate the association of Moyamoya disease with HLA alleles in the Korean population, we investigated HLA class I and class II alleles in 28 Moyamoya patients and 198 unrelated healthy controls. The frequency of HLA-B35 allele was significantly increased in the patients compared to the controls (32.1% vs. 10.1%, RR=4.2, p<0.008). Further analysis of HLA-B35 on onset age and sex showed that this allele was significantly increased compared to the controls in both late-onset and female group. Especially, HLA-B35 was the most significantly increased in female of late-onset group compared to the controls. These results suggest that HLA-B35 may be an useful genetic marker for Moyamoya disease, and particularly in females of late onset group in the Korean population.

Keyword

Moyamoya Disease; HLA-B Antigens; Female; Age of Onset; Korean

MeSH Terms

Adolescent
Adult
Age of Onset
Aged
Child
Child, Preschool
Female
Gene Frequency
*Genes, MHC Class I
*Genes, MHC Class II
Genetic Markers
Genetic Predisposition to Disease
Genotype
HLA Antigens/*genetics
Human
Korea
Male
Middle Aged
Moyamoya Disease/*genetics/*immunology
Retrospective Studies
Support, Non-U.S. Gov't