- The upstream sequence of Mycobacterium leprae 18-kDa gene confers transcription repression activity in orientation-independent manner
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Kim HB, You JC
- KMID: 1103317
- Exp Mol Med.
- 2004 Dec;36(6):510-514.
In order to understand the role of the upstream region of the Mycobacterium leprae 18-kDa gene on the gene regulation, the region was divided into two at the -50 position... -
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- Regulation of ATP-citrate lyase gene transcription
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Kim KS, Kang JG, Moon YA, Park SW, Kim YS
- KMID: 699895
- Yonsei Med J.
- 1996 Jun;37(3):214-224.
- doi: 10.3349/ymj.1996.37.3.214
It has been suggested that glucose metabolites and insulin are the most important factors inducing ATP-citrate lyase (ACL) by a high carbohydrate diet. We have used a primary culture of... -
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- CTCF as a multifunctional protein in genome regulation and gene expression
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Kim S, Yu NK, Kaang BK
- KMID: 2155420
- Exp Mol Med.
- 2015 Jun;47(6):e166.
- doi: 10.1038/emm.2015.33
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator... -
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- Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas
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Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD
- KMID: 1091074
- Exp Mol Med.
- 2007 Dec;39(6):796-804.
Gastric carcinoma is considered to be one of the most prevalent cancers worldwide. We have performed differential-display polymerase chain reaction (DD-PCR) in order to compare the gene expression profile of... -
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- Isolation of ethanol-induced genes in pancreatic beta-cells by representational difference analysis (RDA)
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Shin JS, Kwon YS, Lee JJ, Kim CW
- KMID: 755663
- Exp Mol Med.
- 2004 Feb;36(1):36-42.
Recent epidemiological studies suggest that alcohol consumption is one of the risk factors leading to type 2 diabetes, but the direct effect of ethanol on beta-cell gene expression is not... -
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- Regulation of fatty acid synthase at transcriptional and post-transcriptional levels in rat liver
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Kim KS, Park SW, Kim YS
- KMID: 1120230
- Yonsei Med J.
- 1992 Sep;33(3):199-208.
- doi: 10.3349/ymj.1992.33.3.199
The regulation of fatty acid synthase in rat liver was investigated at transcriptional and post-transcriptional levels. When rats were fasted for 3 days and refed on a high-carbohydrate diet, the... -
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- Hydrogenosomal activity of Trichomonas vaginalis cultivated under different iron conditions
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Kim YS, Song HO, Choi IH, Park SJ, Ryu JS
- KMID: 1088770
- Korean J Parasitol.
- 2006 Dec;44(4):373-378.
- doi: 10.3347/kjp.2006.44.4.373
To evaluate whether iron concentration in TYM medium influence on hydrogenosomal enzyme gene expression and hydrogenosomal membrane potential of Trichomonas vaginalis, trophozoites were cultivated in irondepleted, normal and iron-supplemented TYM... -
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- Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
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Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J
- KMID: 1123768
- Exp Mol Med.
- 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be... -
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- Polycystin-1 Expression in Fetal, Adult and Autosomal Dominant Polycystic Kidney
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Chae SW, Cho EY, Park MS, Lee KB, Kim H, Kim U
- KMID: 1778422
- J Korean Med Sci.
- 2006 Jun;21(3):425-429.
- doi: 10.3346/jkms.2006.21.3.425
The mutation of the PKD1 gene causes autosomal dominant polycystic kidney disease (ADPKD), and the PKD1 gene encodes polycystin-1 (PC-1). PC-1 is thought to be a cell-cell/matrix adhesion receptor molecule... -
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- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform
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Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS
- KMID: 2154232
- Exp Mol Med.
- 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary... -
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- Coordinated transcriptional regulation of calmegin, a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase
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Kim DH, Shim JS, Kwon HJ
- KMID: 1089460
- Exp Mol Med.
- 2005 Oct;37(5):492-496.
Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we revealed that calmegin is transcriptionally... -
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- Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus
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Kim JM, Kim SJ, Lee HC, Kim KS
- KMID: 1110122
- Exp Mol Med.
- 2006 Aug;38(4):385-392.
To develop an inducible expression system, the enhanced artificial nuclear receptors and target reporters were constructed. Artificial nuclear receptors were generated by fusing three domains, consisting of DNA-binding domain (DBD)... -
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- Identification of Up-Regulated Genes in Malignant Glioma with Subtraction Hybridization: Preliminary Screening Studies
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Cho YJ
- KMID: 1084505
- Yonsei Med J.
- 2008 Apr;49(2):301-310.
- doi: 10.3349/ymj.2008.49.2.301
PURPOSE: This investigation is intended to obtain differentially expressed genes related to human malignant glioma using Subtractive hybridization. MATERIALS AND METHODS: Subtractive hybridization is potentially faster methods for identifying differentially... -
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- Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma
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Chen J, Qian Z, Li F, Li J, Lu Y
- KMID: 2412162
- Gut Liver.
- 2017 Jan;11(1):112-120.
- doi: 10.5009/gnl16063
BACKGROUND/AIMS: The integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study... -
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- Gene Expression Analysis of Cultured Amniotic Fluid Cell with Down Syndrome by DNA Microarray
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Chung IH, Lee SH, Lee KW, Park SH, Cha KY, Kim NS, Yoo HS, Kim YS, Lee S
- KMID: 1781731
- J Korean Med Sci.
- 2005 Feb;20(1):82-87.
- doi: 10.3346/jkms.2005.20.1.82
Complete or partial triplication of human chromosome 21 results in Down syndrome (DS). To analyze differential gene expressions in amniotic fluid (AF) cells of DS, we used a DNA microarray... -
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- Expression Profiling of Calcium Induced Genes in Cultured Human Keratinocytes
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Lee JS, Kim MR, Kim NS, Kim YS, Yang JM, Cho AY, Lee Y, Kim CD, Lee JH
- KMID: 1792935
- J Korean Med Sci.
- 2010 Apr;25(4):619-625.
- doi: 10.3346/jkms.2010.25.4.619
Terminal differentiation of skin keratinocytes is a vertically directed multi-step process that is tightly controlled by the sequential expression of a variety of genes. To examine the gene expression profile... -
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- Expression of the RERG Gene is Gender-Dependent in Hepatocellular Carcinoma and Regulated by Histone Deacetyltransferases
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Wang AG, Fang W, Han YH, Cho SM, Choi JY, Lee KH, Kim WH, Kim JM, Park MG, Yu DY, Kim NS, Lee DS
- KMID: 1781911
- J Korean Med Sci.
- 2006 Oct;21(5):891-896.
- doi: 10.3346/jkms.2006.21.5.891
Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In... -
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- miR-526b targets 3' UTR of MMP1 mRNA
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Kim KH, Jung JY, Son ED, Shin DW, Noh M, Lee TR
- KMID: 2155432
- Exp Mol Med.
- 2015 Aug;47(8):e178.
- doi: 10.1038/emm.2015.52
Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1... -
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- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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- Human SNF2L Gene Is Regulated Constitutively and Inducibly in Neural Cells via a cAMP-Response Element
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Xia Y, Wang L, Ma C, Gong Y, Zhao Y
- KMID: 1727896
- Yonsei Med J.
- 2013 May;54(3):772-777.
- doi: 10.3349/ymj.2013.54.3.772
PURPOSE: SNF2L belongs to Imitation Switch family and plays an essential role in neural tissues and gonads. In our previous studies, we have demonstrated that the basal transcription of human... -
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