- Salinomycin reduces stemness and induces apoptosis on human ovarian cancer stem cell
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Lee HG, Shin SJ, Chung HW, Kwon SH, Cha SD, Lee JE, Cho CH
- KMID: 2413456
- J Gynecol Oncol.
- 2017 Mar;28(2):e14.
- doi: 10.3802/jgo.2017.28.e14
OBJECTIVE: Cancer stem cells (CSCs) represent a subpopulation of undifferentiated tumorigenic cells thought to be responsible for tumor initiation, maintenance, drug resistance, and metastasis. The role of CSCs in drug... -
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- Hematoporphyrin monomethyl ether combined with He-Ne laser irradiation-induced apoptosis in canine breast cancer cells through the mitochondrial pathway
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Li H, Tong J, Bao J, Tang D, Tian W, Liu Y
- KMID: 2413173
- J Vet Sci.
- 2016 Jun;17(2):235-242.
- doi: 10.4142/jvs.2016.17.2.235
Hematoporphyrin monomethyl ether (HMME) combined with He-Ne laser irradiation is a novel and promising photodynamic therapy (PDT)-induced apoptosis that can be applied in vitro on canine breast cancer cells. However,... -
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- Downregulation of cellular prion protein inhibited the proliferation and invasion and induced apoptosis of Marek's disease virus-transformed avian T cells
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Wan X, Yang R, Liu G, Zhu M, Zhang T, Liu L, Wu R
- KMID: 2413166
- J Vet Sci.
- 2016 Jun;17(2):171-178.
- doi: 10.4142/jvs.2016.17.2.171
Cellular prion protein (PrP(C)) is ubiquitously expressed in the cytomembrane of a considerable number of eukaryotic cells. Although several studies have investigated the functions of PrP(C) in cell proliferation, cell... -
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- Differential regulation of senescence and in vitro differentiation by 17β-estradiol between mesenchymal stem cells derived from male and female mini-pigs
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Lee WJ, Lee SC, Lee JH, Rho GJ, Lee SL
- KMID: 2413165
- J Vet Sci.
- 2016 Jun;17(2):159-170.
- doi: 10.4142/jvs.2016.17.2.159
The characterization and potential of mesenchymal stem cells (MSCs) are gender dependent and estrogen influences these properties. This study demonstrated that supplementation with 17β-estradiol (E2) increases the proliferation of bone... -
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- Silencing of Long Non-Coding RNA MALAT1 Promotes Apoptosis of Glioma Cells
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Xiang J, Guo S, Jiang S, Xu Y, Li J, Li L, Xiang J
- KMID: 2373664
- J Korean Med Sci.
- 2016 May;31(5):688-694.
- doi: 10.3346/jkms.2016.31.5.688
The metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) is a highly conserved long non-coding RNA (lncRNA) gene. However, little is known about the pathological role of lncRNA MALAT1 in glioma. In... -
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- Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155
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Lee HJ, Lee EJ, Seo M
- KMID: 2466377
- Yonsei Med J.
- 2016 Jan;57(1):247-253.
- doi: 10.3349/ymj.2016.57.1.247
PURPOSE: Apoptosis of vascular endothelial cells is a type of endothelial damage that is associated with the pathogenesis of cardiovascular diseases such as atherosclerosis. Heterotrimeric GTP-binding proteins (G proteins), including... -
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- miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
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Makki MS, Haqqi TM
- KMID: 2160620
- Exp Mol Med.
- 2015 Oct;47(10):e189.
- doi: 10.1038/emm.2015.66
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of... -
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- The Neuroprotective Effect of Maltol against Oxidative Stress on Rat Retinal Neuronal Cells
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Song Y, Hong S, Iizuka Y, Kim CY, Seong GJ
- KMID: 2360139
- Korean J Ophthalmol.
- 2015 Feb;29(1):58-65.
- doi: 10.3341/kjo.2015.29.1.58
PURPOSE: Maltol (3-hydroxy-2-methyl-4-pyrone), formed by the thermal degradation of starch, is found in coffee, caramelized foods, and Korean ginseng root. This study investigated whether maltol could rescue neuroretinal cells from... -
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- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- Developmental changes in cell proliferation and apoptosis in the normal duck bursa of Fabricius
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Fang J, Peng X
- KMID: 2070232
- J Vet Sci.
- 2014 Dec;15(4):465-474.
- doi: 10.4142/jvs.2014.15.4.465
The aim of this work was to investigate developmental changes in cell proliferation and apoptosis in normal duck bursa of Fabricius using flow cytometry and immunohistochemistry. Studies were carried out... -
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- Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
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Lee YA, Kim KA, Min A, Shin MH
- KMID: 1792196
- Korean J Parasitol.
- 2014 Aug;52(4):355-365.
- doi: 10.3347/kjp.2014.52.4.355
The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce... -
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- Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10
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Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL
- KMID: 1737613
- J Vet Sci.
- 2014 Mar;15(1):81-89.
- doi: 10.4142/jvs.2014.15.1.81
Exotoxins produced by Actinobacillus (A.) pleuropneumoniae (Apx) play major roles in the pathogenesis of pleuropneumonia in swine. This study investigated the role of ApxI in hemolysis and cellular damage using... -
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- Heptachlor induced nigral dopaminergic neuronal loss and Parkinsonism-like movement deficits in mice
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Hong S, Hwang J, Kim JY, Shin KS, Kang SJ
- KMID: 2155345
- Exp Mol Med.
- 2014 Feb;46(2):e80.
- doi: 10.1038/emm.2014.12
Epidemiological studies have suggested an association between pesticide exposure and Parkinson's disease. In this study, we examined the neurotoxicity of an organochlorine pesticide, heptachlor, in vitro and in vivo. In... -
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- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- Expression of procaspase 3 and activated caspase 3 and its relevance in hormone-responsive gallbladder carcinoma chemotherapy
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Maurya SK, Tewari M, Sharma B, Shukla HS
- KMID: 1780105
- Korean J Intern Med.
- 2013 Sep;28(5):573-578.
- doi: 10.3904/kjim.2013.28.5.573
BACKGROUND/AIMS: The higher incidence of gallbladder cancer (GBC) in females has been accredited to the involvement of hormones. The clinical implications of sex hormone receptors in GBC are well established.... -
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- Mitochondrial and DNA damage in bovine somatic cell nuclear transfer embryos
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Hwang IS, Bae HK, Cheong HT
- KMID: 1705552
- J Vet Sci.
- 2013 Sep;14(3):235-240.
- doi: 10.4142/jvs.2013.14.3.235
The generation of reactive oxygen species (ROS) and subsequent mitochondrial and DNA damage in bovine somatic cell nuclear transfer (SCNT) embryos were examined. Bovine enucleated oocytes were electrofused with donor... -
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- TDAG51 deficiency promotes oxidative stress-induced apoptosis through the generation of reactive oxygen species in mouse embryonic fibroblasts
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Park ES, Kim J, Ha TU, Choi JS, Hong KS, Rho J
- KMID: 2154254
- Exp Mol Med.
- 2013 Aug;45(8):e35.
Apoptosis has an important role in maintaining tissue homeostasis in cellular stress responses such as inflammation, endoplasmic reticulum stress, and oxidative stress. T-cell death-associated gene 51 (TDAG51) is a member... -
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- Quantitative in Vivo Detection of Brain Cell Death after Hypoxia Ischemia Using the Lipid Peak at 1.3 ppm of Proton Magnetic Resonance Spectroscopy in Neonatal Rats
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Ahn SY, Yoo HS, Lee JH, Sung DK, Jung YJ, Sung SI, Lim KH, Chang YS, Lee JH, Kim KS, Park WS
- KMID: 1777505
- J Korean Med Sci.
- 2013 Jul;28(7):1071-1076.
- doi: 10.3346/jkms.2013.28.7.1071
This study was performed to determine the accuracy of proton magnetic spectroscopy (1H-MRS) lipid peak as a noninvasive tool for quantitative in vivo detection of brain cell death. Seven day-old... -
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- Quantitative Evaluation of Viability- and Apoptosis-Related Genes in Ascaris suum Eggs under Different Culture-Temperature Conditions
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Yu YM, Cho YH, Youn YN, Quan JH, Choi IW, Lee YH
- KMID: 1387413
- Korean J Parasitol.
- 2012 Sep;50(3):243-247.
- doi: 10.3347/kjp.2012.50.3.243
Ascaris suum eggs are inactivated by composting conditions; however, it is difficult to find functional changes in heat-treated A. suum eggs. Here, unembryonated A. suum eggs were incubated at 20degrees... -
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- Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii
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Song KJ, Ahn HJ, Nam HW
- KMID: 1364888
- Korean J Parasitol.
- 2012 Mar;50(1):1-6.
- doi: 10.3347/kjp.2012.50.1.1
Toxoplasma gondii penetrates all kinds of nucleated eukaryotic cells but modulates host cells differently for its intracellular survival. In a previous study, we found out that serine protease inhibitors B3... -
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