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GABA, benzodiazepine receptors and their functions

Chung YC, Han GS

  • KMID: 1691895
  • J Korean Neuropsychiatr Assoc.
  • 1991 May;30(3):431-450.
No abstract available.
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Regional difference in spontaneous firing inhibition by GABA(A) and GABA(B) receptors in nigral dopamine neurons

Kim Y, Jang J, Kim HJ, Park MK

GABAergic control over dopamine (DA) neurons in the substantia nigra is crucial for determining firing rates and patterns. Although GABA activates both GABA(A) and GABA(B) receptors distributed throughout the somatodendritic...
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Effect of GABA on the Contractility of Canine Trachealis Muscle

Koo CH, Kwon OC, Choi EM, Lee KY, Kim WJ

This study aimed to investigate the existence of GABA receptor and the mechanisms of action of GABA and diazepam of the trachealis muscle isolated from dog. Horizontal muscle strips of...
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Molecular mechanisms of general anesthesia

Son Y

General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood....
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Effect of GABA on the contratility of small intestine isolated from rat

Huh JY, Kwon OC, Ha JH, Lee KY, Kim WJ

This study was designed to investigate the effect of GABA and related substances on the spontaneous contraction of rat small intestine. The rats (Sprague-Dawley), weighing 200-250g, were sacrificed by cervical...
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GABA Receptor Imaging

Lee JD

  • KMID: 2313037
  • Nucl Med Mol Imaging.
  • 2007 Apr;41(2):166-171.
GABA is primary an inhibitory neurotransmitter that is localized in inhibitory interneurons. GABA is released from presynaptic terminals and functions by binding to GABA receptors. There are two types of...
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Intraocular Injection of Muscimol Induces Illusory Motion Reversal in Goldfish

Lee SY, Jung CS

Induced activation of the gamma-aminobutyric acidA (GABA(A)) receptor in the retina of goldfish caused the fish to rotate in the opposite direction to that of the spinning pattern during an...
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GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population

Terranova , Tucci M, Di Pietra , Ferrara SD

  • KMID: 2279946
  • Clin Psychopharmacol Neurosci.
  • 2014 Aug;12(2):142-148.
OBJECTIVE: The genes encoding for gamma-aminobutyric acid (GABA) A and B receptors may be considered as candidates for alcoholism; genetic alterations at this level may produce structural and functional diversity...
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Differential Role of Central GABA Receptors in Nociception of Orofacial Area in Rats

Lee AR, Lim NH, Kim HJ, Kim MJ, Ju JS, Park MK, Lee MK, Yang KY, Ahn DK

The present study investigated the role of central GABA(A) and GABA(B) receptors in orofacial pain in rats. Experiments were conducted on Sprague-Dawley rats weighing between 230 and 280 g. Intracisternal...
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The Effects of Repeated Stress on the GABAergic Neurotransmission in Rats

Kim CS, Lee JB, Sung HM, See HS, Kim JS, Park HB, Cheung SD, Ha JH

  • KMID: 2340425
  • J Korean Neuropsychiatr Assoc.
  • 2000 Jan;39(1):190-198.
OBJECTIVES: Changes of GABAergic neurotransmission in response to the application of different types of environmental stress have been the subject of research for over two decades. However, the nature of...
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Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model

Yarishkin , Lee J, Jo S, Hwang EM, Lee CJ

Like neurons, astrocytes produce and release GABA to influence neuronal signaling. At the perforant path to dentate gyrus granule neuron synapse, GABA from astrocyte was found to be a strong...
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Effects of GABA on pancreatic exocrine secretion of rats

Park HS, Park HJ

Since GABA and its related enzymes had been determined in beta-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated perfused rat pancreas. GABA, given intra-arterially...
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Enhancement of GluN2B Subunit-Containing NMDA Receptor Underlies Serotonergic Regulation of Long-Term Potentiation after Critical Period in the Rat Visual Cortex

Joo K, Rhie DJ, Jang HJ

Serotonin [5-hydroxytryptamine (5-HT)] regulates synaptic plasticity in the visual cortex. Although the effects of 5-HT on plasticity showed huge diversity depending on the ages of animals and species, it has...
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Modulatory Effect of Ammonium Carbonate on the GABAA Receptor

Ha JH, Kim WJ, Moon HK

  • KMID: 1961844
  • J Korean Child Neurol Soc.
  • 1998 Oct;6(1):39-46.
PURPOSE: This study was aimed to investigate the modulatory effect of ammonium carbonate on the GABAA receptor. METHODS: The effects of ammonium carbonate on the binding of radioligands to components...
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The Effect of Repeated Stress on the Modulation of Neuroactive Steroids at the GABAA-Benzodiazepine Receptor Complex in Rats

Jang BS, Lee JB, Park HB, Ha JH, Song CJ

  • KMID: 2340326
  • J Korean Neuropsychiatr Assoc.
  • 1999 May;38(3):656-663.
OBJECTIVES: Pregnanolone is a potent positive modulator of the gamma-aminobutyric acid(GABA) response that enhances the binding of [3H]flunitrazepam to the GABA A receptor. Recently, it was reported that chronic...
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Association between Alcoholism and the Genetic Polymorphisms of the GABA(A) Receptor Genes on Chromosome 5q33-34 in Korean Population

Park CS, Park SY, Lee CS, Sohn JW, Hahn GH, Kim BJ

Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. We investigated the association between alcoholism and the genetic polymorphisms of the...
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The effects of etomidate and midazolam on adipose tissue-derived mesenchymal stem cell proliferation

Park H, Ryu K, Kim YH, Choi WJ, Ko D

BACKGROUND: Stem cell therapy using adipose tissue-derived mesenchymal stem cells (ADSCs), which are capable of multipotent differentiation, is currently being investigated in the field of tissue regeneration and the treatment...
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Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms

Joung HY, Kang YM, Lee BJ, Chung SY, Kim KS, Shim I

This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis...
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Inhibitory of γ-aminobutyric acid on the contractility of isolated rat vas deferens

Ahn KY, Kwon OC, Ha JH, Lee KY, Kim WJ

GABA is an inhibitory neurotransmitter in central nervous system and produce sedative, antianxiety and muscle relaxing effects via GABA(A) receptor or GABA(B) receptor. Recently it is known that GABA is...
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Etifoxine for Pain Patients with Anxiety

Choi YM, Kim KH

Etifoxine (etafenoxine, Stresam(R)) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote...
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