- Analysis of Ultraviolet Light Damage in Mammalian Cells by Flowcytometry
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Kim KH, Park KC
- KMID: 2383071
- Ann Dermatol.
- 1995 Apr;7(2):138-143.
- doi: 10.5021/ad.1995.7.2.138
BACKGROUND: Recently the sensitive measurement of radiation damage to DNA using flowcytometric analysis of nucleoid preparations was reported which allows an analysis of damage within the DNA of single cells.... -
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- DNA damage to human genetic disorders with neurodevelopmental defects
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Lee Y, Choi I, Kim J, Kim K
- KMID: 2327696
- J Genet Med.
- 2016 Jun;13(1):1-13.
- doi: 10.5734/JGM.2016.13.1.1
Although some mutations are beneficial and are the driving force behind evolution, it is important to maintain DNA integrity and stability because it contains genetic information. However, in the oxygen-rich... -
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- The Effect of Genetic Variation in The Dna Base Repair Genes on the Risk of Head and Neck Cancer
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Oh JH, Yoon BW, Choi BJ
- KMID: 2005382
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):509-517.
DNA damage accumulates in cells as a result of exposure to exogenous agents such as benzopyrene, cigarette smoke, ultraviolet light, X-ray, and endogenous chemicals including reactive oxygen species produced from... -
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- Inactivation of the NHEJ Activity of DNA-PKcs Prevents Fanconi Anemia Pre-Leukemic HSC Expansion
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Chatla S, Wilson AF, Pang Q
- KMID: 2465886
- Int J Stem Cells.
- 2019 Nov;12(3):457-462.
- doi: 10.15283/ijsc19074
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and high risk of cancer particularly leukemia. Here we show that inactivation of the non-homologous end-joining (NHEJ) activity... -
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- Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review
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Rim KT, Song SW, Kim HY
- KMID: 2317101
- Saf Health Work.
- 2013 Dec;4(4):177-186.
The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative... -
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- Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
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Lee JH, Cheong HM, Kang MY, Kim SY, Kang Y
- KMID: 1982566
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):343-348.
- doi: 10.4196/kjpp.2009.13.5.343
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage... -
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- Molecular Aspects of Radiotherapy
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Park HJ
- KMID: 2200190
- J Lung Cancer.
- 2003 Mar;2(1):10-15.
When tumor cells are exposed to ionizing radiation, various and complicated molecular biological changes take place leading to cell death, mutation, and recovery from sublethal damage. It has been known... -
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- Cell cycle checkpoint control
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Murakami H, Okayama H
- KMID: 2128619
- Exp Mol Med.
- 1997 Mar;29(1):1-11.
Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects... -
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- DNA Damage in Lymphocytes after Hair Dyeing and Related Factors among Women Volunteers
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Cho JA, Oh EH, Sul DG, Lee EI
- KMID: 2283318
- Korean J Prev Med.
- 2002 Nov;35(4):275-281.
OBJECTIVES: To evaluate the DNA damage by hair dyeing in human lymphocytes. METHODS: Comet assays were carried out to evaluate the DNA damage in lymphocytes by hair dyeing. Twenty subjects were... -
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- Comparison of the Protective Effect of Antioxidant Vitamins and Fruits or Vegetable Juices on DNA Damage in Human Lymphocyte Cells Using the Comet Assay
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Jeon EJ, Park YK, Kim JS, Kang MH
- KMID: 2078294
- Korean J Nutr.
- 2004 Jul;37(6):440-447.
In this study the in vitro protective effects of several antioxidant vitamins (vitamin C, alpha-tocopherol, beta-carotene), fruits and vegetables (strawberry, tangerine, orange and 100% orange juice, carrot juice), on the... -
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- Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A
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Lee JS
- KMID: 1522935
- Cancer Res Treat.
- 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well... -
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- The Effects of Purple Grape Juice Supplementation on Improvement of Antioxidant Status and Lymphocyte DNA Damage in Korean Smokers
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Park EJ, Kim JS, Jeon EJ, Kim HY, Park YK, Kang MH
- KMID: 2257458
- Korean J Nutr.
- 2004 May;37(4):281-290.
The purpose of this project was to evaluate whether daily fruit juice consumption could reduce the DNA damage in healthy subjects. The study was performed using 67 healthy volunteers (29... -
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- DNA Damage of Lymphocytes in Volunteers after 4 hours Use of Mobile Phone
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Ji S, Oh E, Sul D, Choi JW, Park H, Lee E
- KMID: 2283777
- J Prev Med Public Health.
- 2004 Nov;37(4):373-380.
OBJECTIVES: There has been gradually increasing concern about the adverse health effects of electromagnetic radiation originating from cell phones which are widely used in modern life. Cell phone radiation may... -
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- The Expressions of p53, gamma-H(2)AX and Ku70/Ku80 That was Caused by Hydronephrosis in the Kidney of Rats
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Moon C, Moon HY, Kim CS
- KMID: 2061301
- Korean J Urol.
- 2007 Sep;48(9):976-983.
- doi: 10.4111/kju.2007.48.9.976
PURPOSE: There are little research about the factors of DNA damage and repair that might cause renal parenchymal damage under the condition of hydronephrosis. In this study, we studied the... -
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- Effect of the Magnetized Water Supplementation on Lymphocyte DNA Damage in Mice Treated with Diethylnitrosamine
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Lee HJ, Jo HR, Jeon EJ, Kang MH
- KMID: 2268053
- Korean J Nutr.
- 2010 Dec;43(6):570-577.
- doi: 10.4163/kjn.2010.43.6.570
Water gets magnetically charged when it is contacted with a magnet. Although magnetic water products have been promoted since the 1930's, they have received very little recognition due to questionable... -
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- Reduction of TNF alpha-induced oxidative DNA damage product, 8-hydroxy-2'-deoxyguanosine, in L929 cells stably transfected with small heat shock protein
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Park YM, Choi EM
- KMID: 1554557
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):209-219.
Previous studies have demonstrated that oxidative stress involving generation of reactive oxygen species (ROS) is responsible for the cytotoxic action of TNF alpha. Protective effect of small heat shock proteins (small HSP) against... -
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- Increased DNA Damage of Lymphocytes in Korean Male Smokers
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Lee J, Lee E, Oh E, Lee J, Sul D, Kim J
- KMID: 792453
- J Prev Med Public Health.
- 2007 Jan;40(1):16-22.
- doi: 10.3961/jpmph.2007.40.1.16
OBJECTIVE: The purpose of this study was to evaluate the levels of DNA damage in human lymphocytes caused by smoking and other lifestyle factors. METHODS: The study population consisted... -
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- The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)
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Seo YR, Jung HJ
- KMID: 1103316
- Exp Mol Med.
- 2004 Dec;36(6):505-509.
The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles... -
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- What should be done for men with sperm DNA fragmentation?
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Kim GY
- KMID: 2419525
- Clin Exp Reprod Med.
- 2018 Sep;45(3):101-109.
- doi: 10.5653/cerm.2018.45.3.101
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF)... -
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- Effects of lymphocyte DNA damage levels in Korean plant food groups and Korean diet regarding to glutathione S-transferase M1 and T1 polymorphisms
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Kim HA, Lee MY, Kang MH
- KMID: 2377977
- J Nutr Health.
- 2017 Feb;50(1):10-24.
- doi: 10.4163/jnh.2017.50.1.10
PURPOSE: GST (glutathione S-transferase) M1 and T1 gene polymorphisms are known to affect antioxidant levels. This study was carried out to evaluate genetic susceptibility by measuring the effect of DNA... -
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