Korean J Hepatol.
2002 Mar;8(1):71-79.
Concurrent Chemo-Radiation Therapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis
- Affiliations
-
- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- BACKGROUND/AIMS: Advanced hepatocellular carcinoma with portal vein thrombosis has a poor prognosis. This study was undertaken to evaluate the therapeutic effects of concurrent chemo-radiation therapy in advanced hepatocellular carcinoma with portal vein thrombosis. METHODS: A total of 54 patients with advanced hepatocellular carcinoma (TNM stage IVa) were enrolled. Nineteen patients were treated with external beam radiotherapy (4,500 cGy/ 5 weeks) and intrahepatic arterial 5-FU infusion (500 mg on 1-5 day and 30-35 day, respectively) via implanted chemoport. The others were treated with intrahepatic arterial cisplatin infusion (80 mg/m2). RESULTS: In patients treated with concurrent chemo-radiation therapy, response rates at 2nd and 6th months were 42.1% and 26.3%, respectively. In patients treated with intrahepatic arterial cisplatin therapy, response rates at 2nd and 6th months were 2.9% and 0%, respectively. The median survival time was 11.6 months in concurrent chemo-radiation therapy and 4.8 months in intrahepatic arterial cisplatin infusion therapy. Concurrent chemo-radiation therapy produced better response rates and longer survival time than those of intrahepatic arterial cisplatin infusion therapy (p<0.05). CONCLUSIONS: Concurrent chemo-radiation therapy achieved favorable results in advanced hepatocellular carcinoma with portal vein thrombosis and can be considered as a treatment option for the management of advanced hepatocellular carcinoma.
Keyword
MeSH Terms
-
Antineoplastic Agents/*administration & dosage
Carcinoma, Hepatocellular/complications/radiotherapy/*therapy
Cisplatin/administration & dosage
Combined Modality Therapy
English Abstract
Female
Fluorouracil/administration & dosage
Human
Infusions, Intra-Arterial
Liver Neoplasms/complications/radiotherapy/*therapy
Male
Middle Aged
*Portal Vein
Prognosis
Venous Thrombosis/*complications
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