Korean J Gastroenterol.
2005 Oct;46(4):269-275.
Grading of Histology, Expression of Apoptosis and Cell Proliferation in Gastric Mucosa Adjacent to Gastric Adenoma or Adenocarcinoma
- Affiliations
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- 1Departments of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. chlee1@cu.ac.kr
- 2Departments of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea.
- 3Departments of Biomedical Statistics, Catholic University of Daegu School of Medicine, Daegu, Korea.
Abstract
- BACKGROUND/AIMS
Helicobacter pylori (H. pylori) infection can lead to gastric adenoma and carcinoma through atrophic gastritis and intestinal metaplasia. Imbalance between apoptosis and proliferation may play a role in gastric carcinogenesis. We tried to investigate H. pylori infection rate, grade of gastritis, environmental risk factors, expression rate of apoptosis and cell proliferation in mucosa adjacent to tumor, and we also tried to find significant factors associated with gastric carcinogenesis. METHODS: Endoscopically diagnosed twenty cases of intestinal type gastric carcinoma, 20 cases of gastric adenoma, and 40 cases of control (normal or gastritis) were enrolled. H. pylori infection rate, histologic grading, apoptosis and immunohistochemical stain (Ki-67 and p53) to check mucosal proliferation were done in endoscopically biopsied tissues at antrum and body at least 2 cm apart from adenoma or carcinoma. RESULTS: In three groups, H. pylori infection rates were not significantly different. In the multivariate analysis, only atrophy of gland was a significant risk factor for adenoma compared to control group (OR 3.7). Intestinal metaplasia in antrum and alcohol drinking were significant risk factors for carcinoma compared to control group (OR 4.4 and 4.9 respectively). Expressions of apoptosis, Ki-67 and p53 were not significantly different in three groups. CONCLUSIONS: Intestinal metaplasia in antrum and alcohol drinking are significant risk factors for gastric carcinoma. Degree of mucosal proliferation and apoptosis in gastric mucosa adjacent to tumor are not significantly different in three groups.
MeSH Terms
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Adenocarcinoma/microbiology/*pathology
Adenoma/microbiology/*pathology
Adult
Aged
Aged, 80 and over
*Apoptosis
*Cell Proliferation
English Abstract
Female
Gastric Mucosa/*pathology
Gastritis/microbiology/pathology
Helicobacter Infections/complications/pathology
Helicobacter pylori
Humans
Male
Middle Aged
Risk Factors
Stomach Neoplasms/microbiology/*pathology
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