J Korean Gastric Cancer Assoc.
2006 Jun;6(2):91-96.
Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma
- Affiliations
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- 1Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. endoscope@hanmail.net
Abstract
- PURPOSE
Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover. We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas.
MATERIALS AND METHODS
The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were performed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters.
RESULTS
The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters.
CONCLUSION
We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas.
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