Exp Mol Med.
2008 Jun;40(3):294-303. 10.3858/emm.2008.40.3.294.
Local exposure of 849 MHz and 1763 MHz radiofrequency radiation to mouse heads does not induce cell death or cell proliferation in brain
- Affiliations
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- 1ILCHUN Genomic Medicine Institute, MRC, Seoul National University College of Medicine , Seoul 110-799, Korea. wypark@snu.ac.kr
- 2Department of Biochemistry and Molecular Biology and Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea.
- 3Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea.
- 4Department of Neurology, Seoul National University College of Medicine, Seoul 110-799, Korea.
- 5Department of Dental Anesthesiology, School of Dentistry, Seoul National University, Seoul 110-799, Korea.
- 6Laboratory of Radiation Molecular Cancer Biology, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea.
- 7Department of Radio Sciences and Engineering, College of Engineering, Chungnam National University, Daejon 305-764, Korea.
- KMID: 756331
- DOI: http://doi.org/10.3858/emm.2008.40.3.294
Abstract
- Even though there is no direct evidence to prove the cellular and molecular changes induced by radiofrequency (RF) radiation itself, we cannot completely exclude the possibility of any biological effect of mobile phone frequency radiation. We established a carousel-type exposure chamber for 849 MHz or 1763 MHz of mobile phone RF radiation to expose RF to the heads of C57BL mice. In this chamber, animals were irradiated intermittently at 7.8 W/kg for a maximum of 12 months. During this period, the body weights of 3 groups-sham, 849 MHz RF, and 1763 MHz RF-did not show any differences between groups. The brain tissues were obtained from 3 groups at 6 months and 12 months to examine the differences in histology and cell proliferation between control and RF exposure groups, but we could not find any change upon RF radiation. Likewise, we could not find changes in the expression and distribution of NeuN and GFAP in hippocampus and cerebellum, or in cell death by TUNEL assay in RF exposure groups. From these data, we conclude that the chronic exposure to 849 MHz and 1763 MHz RF radiation at a 7.8 W/kg specific absorption rate (SAR) could not induce cellular alterations such as proliferation, death, and reactive gliosis.
Keyword
MeSH Terms
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Animals
Apoptosis/*radiation effects
Body Weight/radiation effects
Brain/pathology/*radiation effects
Cell Proliferation/*radiation effects
*Cellular Phone
Dose-Response Relationship, Radiation
Gliosis/etiology/pathology
In Situ Nick-End Labeling
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins/biosynthesis/genetics
Proliferating Cell Nuclear Antigen/biosynthesis/genetics
Radio Waves/*adverse effects
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