Exp Mol Med.
2000 Dec;32(4):231-234.
Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Korea University Anam Hospital, Seoul.
Abstract
- The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases of Korean idiopathic azoospermia and 6 of Korean non-mosaic type of Klinefelter syndrome were used for the detection of Y chromosome microdeletions by polymerase chain reaction using 60 primers. Microdeletions of the Y chromosome were found in 1 of 9 (11.1%) patients with idiopathic azoospermia, whereas none was deleted in non-mosaic type of Klinefelter syndrome. This result suggests that Y chromosome microdeletions could be one of the etiologic factors in idiopathic azoospermia.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Detection of the Microdeletion on the Y Chromosome of Patients with Idiopathic Oligospermia or Azoospermia
- Genetic Screening for Chromosomal Abnormalities and Y Chromosome Microdeletions in 846 Infertile Korean Men
- Prevalence of Y chromosome microdeletions among infertile Mongolian men
- Klinefelter's Syndrome
- Outcome of Microsurgical Multiple Testicular Sperm Extraction for Patients with Y Chromosome Microdeletion
