Clin Exp Reprod Med.  2022 Jun;49(2):101-109. 10.5653/cerm.2021.05099.

Prevalence of Y chromosome microdeletions among infertile Mongolian men

• Damdinsuren E
• Naidansuren P
• Gochoo M
• Choi BC
• Choi MY
• Baldandorj B

• KMID: 2531711
• DOI: http://doi.org/10.5653/cerm.2021.05099

Abstract

Objective
Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men.
Methods
A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined.
Results
Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%.
Conclusion
The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.

Keyword

Azoospermia; Infertility; Semen analysis; Y chromosome