Korean J Ophthalmol.  2004 Dec;18(2):89-99. 10.3341/kjo.2004.18.2.89.

Correlation Between Frequency Doubling Technology Perimetry and Scanning Laser Polarimetry in Glaucoma Suspects and Glaucomatous Eyes

• Kim SH
• Hong H
• Koo HJ
• Yang SJ
• Tchah H
• Kook MS

• KMID: 754373
• DOI: http://doi.org/10.3341/kjo.2004.18.2.89

Abstract

The aim of this study was to determine the relationship between the frequency doubling technology (FDT) screening algorithm and parapapillary retinal nerve fiber layer (RNFL) thickness in the eyes of glaucoma suspects and patients with open angle glaucoma. FDT C20-1 screening program and a scanning laser polarimetry (SLP) system (GDx-NFA) was used to assess 53 glaucomatous eyes, 53 glaucoma suspects and 36 normal control eyes. In glaucomatous eyes, there were correlations between the FDT the screening algorithm and RNFL retardation values in several polarimetric indices, most significantly "inferior thickness" (r = -0.321, P = 0.029). In the eyes of glaucoma suspects, however, we observed no correlation between the FDT results and RNFL retardation values (r = 0.080, P > 0.05, "inferior thickness"). In glaucomatous eyes, the abnormal scores obtained with FDT screening program correlated negatively with RNFL retardation values, as measured by SLP. Despite poor correlation between the FDT abnormal score and RNFL retardation value in glaucoma suspects, detection of abnormality using the FDT screening protocol may aid in the assessment of early glaucomatous structural damage.

Keyword

frequency doubling technology perimetry (FDT) ; glaucoma; glaucoma suspects; retinal nerve fiber layer (RNFL) ; scanning laser polarimetry (SLP)

MeSH Terms

Comparative Study
Glaucoma, Open-Angle/*diagnosis/physiopathology
Humans
Intraocular Pressure
Lasers/diagnostic use
Microscopy, Confocal
Middle Aged
Nerve Fibers/*pathology
Ocular Hypertension/diagnosis/physiopathology
Optic Nerve/*pathology
Perimetry/*methods
Retinal Ganglion Cells/*pathology