Yonsei Med J.  1998 Jun;39(3):196-201. 10.3349/ymj.1998.39.3.196.

Primary lymphoma of the eye

• Hahn JS
• Suh CO
• Lee SY
• Yang WI

• KMID: 711547
• DOI: http://doi.org/10.3349/ymj.1998.39.3.196

Abstract

Lymphomas in the eye tend to be localized and to have a better prognosis. We reviewed the clinical presentation, treatment outcome and complications of primary lymphomas of the eye at a single institute focusing on the clinical significance of adequate staging and the prognostic value of pathological subtypes. Twenty-four patients with lymphoproliferative lesion of the eye were treated and followed up. The orbit was the most commonly involved site. Twenty-one patients had unilateral diseases and three patients had bilateral. Histological findings revealed 22 malignant lymphomas, one inflammatory pseudotumor and one atypical lymphoid hyperplasia. Using the NCI Working Formulation, most of the malignant lymphomas were primarily low grade: diffuse small lymphocytic, 15; diffuse small cleaved three; diffuse large cell, three; and diffuse mixed, one. The stages of lymphoma were IAE in 21 patients, IBE in one patient, and IIAE in two patients. Twenty-five of the 27 treated eyes remained disease-free during the median follow-up period of 16 months. Nineteen patients received radiotherapy, five patients received chemo-radiotherapy and one patient received only surgical excision. Two patients relapsed outside the treated field. None of the patients complained of severe dry eye syndrome or cataract formation. In conclusion, after complete staging work-up, locally-confined low grade orbital lymphomas can be up to 90% controlled with radiotherapy alone. By contrast, combined treatment is advised in patients with intermediate and high grade lesions.

Keyword

Orbital lymphoma; radiotherapy; low grade

MeSH Terms

Adolescence
Adult
Aged
Antineoplastic Agents, Combined/therapeutic use
Combined Modality Therapy
Eye Neoplasms/radiotherapy*
Eye Neoplasms/pathology*
Eye Neoplasms/drug therapy
Female
Human
Lymphoma/radiotherapy*
Lymphoma/pathology*
Lymphoma/drug therapy
Male
Middle Age
Neoplasm Staging
Survival Analysis