Yonsei Med J.  1969 Jun;10(1):10-18. 10.3349/ymj.1969.10.1.10.

Influence of Corticosteroids on the Hepatic Cell and Bile Secretion (1)

• Kim YH
• Lee YB
• Hong SS

• KMID: 687608
• DOI: http://doi.org/10.3349/ymj.1969.10.1.10

Abstract

Daily administration of glucocorticoids for 10 days to dogs resulted in a significant increase in the hepatic bile secretion in response to secretory stimulants. The response of hepatic bile in testosterone-treated animals was not changed and the response was increased in DOCA--treated animals. A significant increase of liver weight was induced by the animals receiving glucocorticoids. Other organ weight was not changed; however, a slight reduction of kidney weight was seen in prednisolone, dexamethasone, and DOCA treated animals and also in animals supplemented with cortisone following adrenalectomy. The presence of large areas of ballooning and vesicular changes of liver cells was seen in glucocorticoid treated animals, particularly in cases of dexamethasone and prednisolone. Both vesicular changes of liver cell and its glycogen content were increased by the repeated administration of prednisolone and reduced by the cessation of treatment. Special stain and liver glycogen determination demonstrated the material distending the liver cell was glycogen. These findings indicate that long term administration of glucocorticoids results in an increase of liver weight and hepatic glycogen content as well as increased bile secretion.

MeSH Terms

Animal
Bile/secretion*
Bile Acids and Salts/metabolism
Bilirubin/secretion
Cholagogues and Choleretics/pharmacology
Dogs
Glucocorticoids/pharmacology*
Liver/drug effects*
Liver/pathology
Liver Glycogen/metabolism
Organ Weight
Substances:
Bile Acids and Salts
Cholagogues and Choleretics
Glucocorticoids
Liver Glycogen
Bilirubin