J Korean Med Sci.  2002 Dec;17(6):755-760. 10.3346/jkms.2002.17.6.755.

Circulating IL-8 and IL-10 in Euthyroid Sick Syndromes following Bone Marrow Transplantation

• Lee WY
• Suh JY
• Kim SW
• Oh ES
• Oh KW
• Baek KH
• Kang MI
• Lee KW
• Kim CC

• KMID: 648783
• DOI: http://doi.org/10.3346/jkms.2002.17.6.755

Abstract

It is generally agreed that euthyroid sick syndromes (ESS) are associated with an increased production of cytokines. However, there has been scarce data on the relationship thyroid hormone changes and cytokines among the patients undergoing bone marrow transplantation (BMT). Because interleukin-8 (IL-8) has been identified as a potent proinflammatory and interleukin-10 (IL-10) as an antiinflammatory cytokine, we studied the relation between thyroid hormone parameters and these cytokines following BMT. We studied 80 patients undergoing allogeneic BMT. Serum T3 decreased to nadir at post-BMT 3 weeks. Serum T4 was the lowest at the post-BMT 3 months. Serum TSH sharply decreased to nadir at 1 week and gradually recovered. Serum free T4 significantly increased during 3 weeks and then returned to basal level. Mean levels of serum IL-8 significantly increased at 1 week after BMT. Mean levels of serum IL-10 significantly increased until 4 weeks after BMT. No significant correlation was found between serum thyroid hormone parameters and cytokines (IL-8, IL-10) after adjusting steroid doses during the entire study period. In conclusion, ESS developed frequently following allogeneic BMT and cytokine levels were increased in post-BMT patients. However, no significant correlation was found between serum thyroid hormone parameters and these cytokines.

Keyword

Euthyroid Sick Syndromes; Bone Marrow Transplantation; Interleukin-8; Interleukin-10

MeSH Terms

Adult
*Bone Marrow Transplantation
Euthyroid Sick Syndromes/*blood
Female
Humans
Interleukin-10/*blood
Interleukin-8/*blood
Male
Middle Aged
Thyroxine/blood
Time Factors
Triiodothyronine/blood