J Korean Med Sci.
2001 Aug;16(4):407-410. 10.3346/jkms.2001.16.4.407.
Increased levels of Circulating Autoantibodies to Cultured Human Bronchial Epithelial Cell in Adult Patients with Nonatopic Asthma
- Affiliations
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- 1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon. dhnahm@madang.ajou.ac.kr
- 2Department of Pathology School of Medicine, Suwon.
- 3The Laboratory of Endocrinology, Ajou University School of Medicine, Suwon.
- 4Department of Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul.
- 5Department of Microbiology, Changwon National University, Changwon, Korea.
- KMID: 648297
- DOI: http://doi.org/10.3346/jkms.2001.16.4.407
Abstract
- The pathogenetic mechanism of nonatopic asthma has not yet been defined. The idea of a possible involvement of autoimmunity in the pathogenesis of nonatopic asthma has been proposed by earlier studies. To evaluate the possible involvement of autoimmune response against bronchial epithelial cell in the pathogenesis of nonatopic asthma, we measured circulating autoantibodies to cultured human bronchial epithelial cell (BEAS-2B cell line) using enzyme-linked immunosorbent assay. We used stored serum samples form 38 age-matched healthy controls, 26 adult patients with atopic asthma, 16 adult patients with nonatopic asthma, and 12 adult patients with systemic lupus erythematosus. Levels of IgG autoantibodies to bronchial epithelial cell were significantly higher in patients with nonatopic asthma (mean+/-SD of absorbance values; 0.135+/-0.030) and systemic lupus erythematosus (0.293+/-0.181) than in healthy controls (0.112+/-0.016) and patients with atopic asthma (0.116+/-0.031) (p<0.05). This study showed that levels of circulating IgG autoantibodies to bronchial epithelial cell were increased in adult patients with nonatopic asthma. Further studies are needed to evaluate the possible involvement of autoimmune mechanism in the pathogenesis of nonatopic asthma.
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Cited by 2 articles
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Autoimmune Responses in Severe Asthma
Manali Mukherjee, Parameswaran Nair
Allergy Asthma Immunol Res. 2018;10(5):428-447. doi: 10.4168/aair.2018.10.5.428.Sputum Autoantibodies Are More Relevant in Autoimmune Responses in Asthma than Are Serum Autoantibodies
Rundong Qin, Fei Long, Xiaojun Xiao, Jing Xiao, Zhengyu Zheng, Mulin Feng, Renbin Huang, Tao Peng, Jing Li
Allergy Asthma Immunol Res. 2019;11(3):406-421. doi: 10.4168/aair.2019.11.3.406.
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