J Korean Med Sci.  2000 Apr;15(2):243-246. 10.3346/jkms.2000.15.2.243.

Myelomatous effusion with poor response to chemotherapy

• Kim YM
• Lee KK
• Oh HS
• Park SK
• Won JH
• Hong DS
• Park HS
• Park JS
• Lee DW

• KMID: 648132
• DOI: http://doi.org/10.3346/jkms.2000.15.2.243

Abstract

While pleural effusion in multiple myeloma is relatively infrequent, myelomatous pleural effusion is extremely rare. We experienced a 61-year-old woman with IgD-lambda multiple myeloma and pleural effusion. The diagnosis was made originally by pleural biopsy, pleural fluid cytology and immunoelectropheresis of pleural fluid. Transient improvement of the pleural effusion was observed after administration of combination chemotherapy of vincristine, melphalan, cyclophosphamide, prednisone (VMCP)/vincristine, cyclophosphamide, adriamycin, prednisone (VCAP). Two months later, myelomatous pleural effusion recurred and no response to salvage therapy was observed. We reviewed the clinical feature of this case and literature concerning myelomatous pleural effusion.

Keyword

Multiple Myeloma; Pleural Effusion; Drug Therapy

MeSH Terms

Antineoplastic Agents, Combined/administration & dosage*
Case Report
Cyclophosphamide/administration & dosage
Female
Human
Melphalan/administration & dosage
Middle Age
Multiple Myeloma/pathology
Multiple Myeloma/drug therapy*
Multiple Myeloma/complications*
Plasma Cells/pathology
Pleural Effusion/radiography
Pleural Effusion/pathology
Pleural Effusion/etiology*
Prednisone/administration & dosage
Tomography, X-Ray Computed
Vincristine/administration & dosage