Nutr Res Pract.
2025 Apr;19(2):186-199. 10.4162/nrp.2025.19.2.186.
Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart
- Affiliations
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- 1Institute of Sports and Arts Convergence (ISAC), Inha University, Incheon 22212, Korea
- 2Institute for Specialized Teaching and Research, Inha University, Incheon 22212, Korea
- 3Department of Kinesiology, Inha University, Incheon 22212, Korea
- 4Department of Biomedical Science and Engineering, Inha University, Incheon 22212, Korea
- 5Department of Pharmacology, College of Medicine, Inha University, Incheon 22212, Korea
- 6Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
- 7National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
- KMID: 2566808
- DOI: http://doi.org/10.4162/nrp.2025.19.2.186
Abstract
- BACKGROUD/OBJECTIVES: Resveratrol, a natural polyphenolic compound, has potent antioxidant and anti-inflammatory properties, leading to beneficial effects against cardiovascular diseases. The purpose of this study was to determine whether resveratrol induces protective effects against aging-induced cardiac remodeling, mitochondrial dysfunction, and mitochondria-mediated apoptosis in the heart.
MATERIALS/METHODS
Thirty-two male Fischer 344 rats were divided into 4 groups: 2 groups that were orally treated with resveratrol (50 mg/kg/day) for 6 weeks (young and old resveratrol groups), and 2 control groups (young and old control groups). Mitochondrial function and mitochondria-mediated apoptotic pathway were analyzed in cardiac muscle fibers from the left ventricle.
RESULTS
Resveratrol significantly reduced cardiac hypertrophy and remodeling in aging hearts. In addition, resveratrol significantly ameliorated aging-induced mitochondrial dysfunction (e.g., decreased oxygen respiration and increased hydrogen peroxide emission) and mitochondria-dependent apoptotic signaling (the Bax/Bcl-2 ratio, mitochondrial permeability transition pore opening sensitivity, and cleaved caspase-3 protein levels). Resveratrol also significantly attenuated aging-induced apoptosis (determined via cleaved caspase-3 staining and TUNEL-positive myonuclei) in cardiac muscles.
CONCLUSION
This study demonstrates that resveratrol treatment has a beneficial effect on aging-induced cardiac remodeling by ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptosis in the heart.
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