Infect Chemother.
2025 Mar;57(1):161-167. 10.3947/ic.2024.0111.
Linezolid-Resistant Coagulase-Negative Staphylococci in a Tertiary Hospital: Molecular Epidemiology, Clinical Characteristics, and Outcomes
- Rachina S
1 - Gostev V2,3
- Pleshkov V2,4
- Karpova O1
- Topolyanskaya S1
- Melkonyan G5,6
- Gladkikh M5
- Zainalabidova K1
- Chulkova P2,3
- Sidorenko S2,3
- Affiliations
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- 1I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation
- 2Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation
- 3North-Western State Medical University Named After I. I. Mechnikov, Saint Petersburg, Russian Federation
- 4Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine, Saint Petersburg, Russian Federation
- 5War Veterans Hospital Nº3, Moscow, Russian Federation
- 6Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
- KMID: 2566771
- DOI: http://doi.org/10.3947/ic.2024.0111
Abstract
- We report linezolid-resistant coagulase-negative Staphylococcus (LRCoNS) bacteremia at a tertiary hospital. LRCoNS with linezolid and tedizolid minimum inhibitory concentrations of >32 and 4–32 mg/L, respectively, were isolated from blood cultures of seven elderly patients who died post-bacteremia detection. Linezolid was administered to six of these patients at the time of LRCoNS isolation. Linezolid-resistant S. epidermidis ST5 isolates (LRSE) harboring mecA were isolated in seven of the nine episodes. Linezolid resistance is associated with mutations in the 23S rRNA, L3 and L4 ribosomal proteins, indigenous methyltransferases RlmN, and the presence of the cfr gene. All LRSE-ST5 genomes formed a single phylogenetic cluster.
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