J Vet Sci.  2013 Dec;14(4):449-456. 10.4142/jvs.2013.14.4.449.

Prevalence and risk factors for carriage of multi-drug resistant Staphylococci in healthy cats and dogs

• Gandolfi-Decristophoris P
• Regula G
• Petrini O
• Zinsstag J
• Schelling

• KMID: 1712312
• DOI: http://doi.org/10.4142/jvs.2013.14.4.449

Abstract

We investigated the distribution of commensal staphylococcal species and determined the prevalence of multi-drug resistance in healthy cats and dogs. Risk factors associated with the carriage of multi-drug resistant strains were explored. Isolates from 256 dogs and 277 cats were identified at the species level using matrix-assisted laser desorption ionisation-time of flight mass spectrometry. The diversity of coagulase-negative Staphylococci (CNS) was high, with 22 species in dogs and 24 in cats. Multi-drug resistance was frequent (17%) and not always associated with the presence of the mecA gene. A stay in a veterinary clinic in the last year was associated with an increased risk of colonisation by multi-drug resistant Staphylococci (OR = 2.4, 95% CI: 1.1~5.2, p value LRT = 0.04). When identifying efficient control strategies against antibiotic resistance, the presence of mechanisms other than methicillin resistance and the possible role of CNS in the spread of resistance determinants should be considered.

Keyword

antibiotics; coagulase-negative; matrix-assisted laser desorption ionisation-time of flight; staphylococci

MeSH Terms

Animals
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/genetics/metabolism
Cat Diseases/epidemiology/*microbiology
Cats
Coagulase/genetics/metabolism
Dog Diseases/epidemiology/*microbiology
Dogs
*Drug Resistance, Multiple, Bacterial
Female
Male
Prevalence
Risk Factors
Seasons
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/veterinary
Staphylococcal Infections/epidemiology/microbiology/*veterinary
Staphylococcus/classification/genetics/*isolation & purification
Switzerland/epidemiology
Anti-Bacterial Agents
Bacterial Proteins
Coagulase

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