Korean J Geriatr Gerontol.  2024 Apr;25(1):49-59. 10.15656/kjgg.2024.25.1.49.

Relationship between Osteoarthritis and Atopic Dermatitis Based on the 3rd-8th Korea National Health and Nutrition Examination Survey

• Kim S

• KMID: 2566334
• DOI: http://doi.org/10.15656/kjgg.2024.25.1.49

Abstract

Background
Evidence has been raised on the genetic link between osteoarthritis and allergic conditions, and recent studies have confirmed the association between asthma and osteoarthritis. However, the relationship between atopic dermatitis and osteoarthritis has not been sufficiently investigated. This study aimed to assess the association between atopic dermatitis and osteoarthritis in Korean adults.
Methods
Multiple logistic and linear regression models were fitted utilizing data from the 3rd-8th Korea National Health and Nutrition Examination Survey to assess the relationship between atopic dermatitis and osteoarthritis with adjustment for potential confounding factors among men and women in their 50s.
Results
After adjustment for potential confounding factors, doctor-diagnosed osteoarthritis was significantly more prevalent in men and women with atopic dermatitis (adjusted odds ratio: 2.27 [95% confidence interval: 1.05-4.88]; P=0.037 and 2.95 [2.04-4.25]; P<0.001, respectively). When adjusted for potential confounders, knee pain (3.13 [1.42-6.92]; P=0.005), symptomatic knee osteoarthritis (3.23 [1.01-10.39]; P=0.049), and symptomatic lumbar osteoarthritis (6.97 [2.97-16.37]; P<0.001) were also significantly more frequent in women with atopic dermatitis. Furthermore, knee pain was observed to be more severe in women with atopic dermatitis after adjustment for confounders (adjusted mean difference: 1.43 [0.26-2.59]; P=0.016).
Conclusion
These results indicate that atopic dermatitis is associated with osteoarthritis in Korean adults in their 50s.

Keyword

Atopic dermatitis; Knee; Osteoarthritis