Korean J Health Promot.  2023 Dec;23(4):198-208. 10.15384/kjhp.2023.23.4.198.

Association between Atopic Dermatitis and Hyperuricemia in the Adult Korean Population based on the 7th and 8th Korea National Health and Nutrition Examination Survey

• Kim S

• KMID: 2549690
• DOI: http://doi.org/10.15384/kjhp.2023.23.4.198

Abstract

Background
Serum uric acid levels have been reported to be associated with various conditions including psoriasis and metabolic syndrome, but their relationship with atopic dermatitis has not been studied adequately. This study aimed to investigate the association of atopic dermatitis with serum uric acid level and hyperuricemia in adult females and males.
Methods
Using data from the 7th and 8th Korea National Health and Nutrition Examination Survey, multiple linear and logistic regression analyses were performed to assess the association of atopic dermatitis with serum uric acid level and hyperuricemia respectively, with adjustment for potential confounding factors in females and males aged 19 years or older, respectively.
Results
The study population included 14,504 female and 12,147 male participants. When adjusting for potential confounding factors, females with atopic dermatitis had a mean serum uric acid level of 0.13 mg/dL (95% confidence interval [CI], 0.03-0.24) higher than those without atopic dermatitis (P=0.013), and hyperuricemia was also more frequent in females with atopic dermatitis than those without atopic dermatitis (adjusted odds ratio, 1.86; 95% CI, 1.27-2.72; P=0.002). On the other hand, there were no significant differences in mean serum uric acid level and frequency of hyperuricemia between males with and without atopic dermatitis when adjusting for potential confounding factors.
Conclusions
These results show a close relationship of atopic dermatitis with elevated serum uric acid level and hyperuricemia in Korean adult females but not males.

Keyword

Atopic dermatitis, Uric acid, Hyperuricemia; 아토피피부염, 요산, 고요산혈증

Figure

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  Figure 1. Flow chart of the study population. HDL, high-density lipoprotein.

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  Figure 2. Box plots showing the distributions of serum uric acid levels in adult females and males with and without atopic dermatitis.

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  Figure 3. Estimated marginal mean serum uric acid levels in adult females and males with and without atopic dermatitis. The error bars indicate 95% confidence intervals. The results were obtained by multiple linear regression analyses with adjustment for potential confounding factors including age, education, household income, alcohol intake, smoking, physical activity, resistance exercise, abdominal obesity, elevated fasting glucose, high triglycerides, low high-density lipoprotein-cholesterol, elevated blood pressure, and serum creatinine using generalized linear model for complex survey design.

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