Clin Orthop Surg.
2025 Apr;17(2):187-193. 10.4055/cios24301.
Hyperlipidemia and Rotator Cuff Tears: Exploring Mechanisms and Effective Treatment
- Affiliations
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- 1Department of Orthopedic Surgery, Kyungpook National University Hospital, Daegu, Korea
- 2Department of Orthopedic Surgery, Konkuk University Medical Center, Seoul, Korea
- 3Department of Orthopedic Surgery, Daegu Catholic University School of Medicine, Daegu, Korea
- 4Department of Orthopedic Surgery, Keimyung University School of Medicine, Daegu, Korea
- KMID: 2565819
- DOI: http://doi.org/10.4055/cios24301
Abstract
- The detrimental effects of hyperlipidemia on the healing of rotator cuff tears are well documented. The proposed underlying mechanisms for these effects include alterations in the extracellular matrix, inflammation, and oxidative stress, which hamper the reparative processes in the affected tendon tissues. Recent therapeutic strategies target these pathways, reflecting a growing body of research dedicated to mitigating these effects and promoting healing. This literature review aims to provide a comprehensive understanding of the pathophysiology underlying rotator cuff tears, examine the interplay between hyperlipidemia and rotator cuff tear healing, synthesize current knowledge on contributing biological mechanisms, and outline potential therapeutic interventions to optimize clinical management and treatment outcomes for patients.
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