Clin Orthop Surg.  2023 Dec;15(6):873-879. 10.4055/cios23131.

Current Research on the Influence of Statin Treatment on Rotator Cuff Healing

• Yoon JP
• Park SJ
• Kim DH
• Shim BJ
• Chung SW

• KMID: 2548249
• DOI: http://doi.org/10.4055/cios23131

Abstract

Rotator cuff tears are a condition characterized by damage to the muscles and tendons that connect the scapula and humerus, which are responsible for shoulder rotation and arm lifting. Metabolic factors such as diabetes, thyroid disease, high cholesterol, vitamin D deficiency, obesity, and smoking have been associated with an increased risk of rotator cuff tears. Interestingly, patients with hyperlipidemia, a condition characterized by high levels of cholesterol and other fats in the blood, have been found to have a higher incidence of rotator cuff tears and breakdown of tendon matrix. As a result, statin therapy, which is commonly used to lower cholesterol levels in hyperlipidemia, has been explored as a potential treatment to improve clinical outcomes in rotator cuff tears. However, the results of preclinical and clinical studies on the effects of statins on tendon healing in rotator cuff tears are limited and not well-defined. Moreover, since hyperlipidemia and rotator cuff tears are more prevalent in older individuals, a literature review on the efficacy and safety of statin therapy in this population is needed.

Keyword

Statin; Rotator cuff; Tendon healing; Lipid-lowering therapy; Hyperlipidemia