Int J Stem Cells.
2025 Feb;18(1):21-36. 10.15283/ijsc23169.
Stem Cell-Based Approaches in Parkinson’s Disease Research
- Affiliations
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- 1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 3Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea
- 4Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea
- 5KHU-KIST Department of Converging Science and Technology, Graduate School, Kyung Hee University, Seoul, Korea
- 6The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- KMID: 2565194
- DOI: http://doi.org/10.15283/ijsc23169
Abstract
- Parkinson’s disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don’t alter disease progression. Stem cell technology, involving patient-specific stem cell-derived neurons, offers a promising avenue for research and personalized regenerative therapies. This article reviews the potential of stem cell-based research in PD, summarizing ongoing efforts, their limitations, and introducing innovative research models. The integration of stem cell technology and advanced models promises to enhance our understanding and treatment strategies for PD.
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