Epidemiol Health.
2024;46(1):e2024062. 10.4178/epih.e2024062.
Introduction to the forensic research via omics markers in environmental health vulnerable areas (FROM) study
- Kwon JY
1 - Kim WJ2
- Cho YM3
- Kim Bg1,4
- Lee S1,4
- Rho JH1
- Eom SY5
- Han D3
- Choi KH6
- Lee JH7
- Kim J2
- Won S8
- Kang HG9
- Mun S9
- Yoo HJ10
- Kim JW11
- Lee K12
- Park WJ13
- Hong S14
- Hong YS1,4
- Affiliations
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- 1Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea
- 2Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, Korea
- 3Department of Nano, Chemical & Biological Engineering, Seokyeong University, Seoul, Korea
- 4Environmental Health Center for Busan, Dong-A University, Busan, Korea
- 5Department of Preventive Medicine, Chungbuk National University College of Medicine, Cheongju, Korea
- 6Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea
- 7SD Medical Research Institute, Yongin, Korea
- 8Department of Public Health Sciences, Seoul National University, Seoul, Korea
- 9Department of Biomedical Laboratory Science, Eulji University College of Health Sciences, Seongnam, Korea
- 10Department of Convergence Medicine, Department of Digital Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 11Department of Life Sciences, Chung-Ang University, Seoul, Korea
- 12Department of Preventive Medicine, Dongguk University College of Medicine, Gyeongju, Korea
- 13Department of Occupational and Environmental Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, Korea
- 14Department of Preventive Medicine, Jeju National University College of Medicine, Jeju, Korea
- KMID: 2564533
- DOI: http://doi.org/10.4178/epih.e2024062
Abstract
- This research group (forensic research via omics markers in environmental health vulnerable areas: FROM) aimed to develop biomarkers for exposure to environmental hazards and diseases, assess environmental diseases, and apply and verify these biomarkers in environmentally vulnerable areas. Environmentally vulnerable areas—including refineries, abandoned metal mines, coal-fired power plants, waste incinerators, cement factories, and areas with high exposure to particulate matter—along with control areas, were selected for epidemiological investigations. A total of 1,157 adults, who had resided in these areas for over 10 years, were recruited between June 2021 and September 2023. Personal characteristics of the study participants were gathered through a survey. Biological samples, specifically blood and urine, were collected during the field investigations, separated under refrigerated conditions, and then transported to the laboratory for biomarker analysis. Analyses of heavy metals, environmental hazards, and adducts were conducted on these blood and urine samples. Additionally, omics analyses of epigenomes, proteomes, and metabolomes were performed using the blood samples. The biomarkers identified in this study will be utilized to assess the risk of environmental disease occurrence and to evaluate the impact on the health of residents in environmentally vulnerable areas, following the validation of diagnostic accuracy for these diseases.
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