J Korean Dent Sci.  2024 Dec;17(4):174-186. 10.5856/JKDS.2024.17.4.174.

Inflammaging: Molecular Pathways and Implications in Oral Pathology

• Lyoo SH
• Kim KW

• KMID: 2564308
• DOI: http://doi.org/10.5856/JKDS.2024.17.4.174

Abstract

Inflammaging is known to be an aging-associated chronic, low-grade inflammatory state that significantly influences the pathophysiology of various age-related diseases, including those affecting oral health. This review explores the molecular and cellular mechanisms of inflammaging and its implications in oral pathology. We will review key factors contributing to inflammaging, including cellular senescence, and immune dysregulation, all of which induce pro-inflammatory cytokines and reactive oxygen species (ROS). These inflammatory mediators affect oral tissues, predisposing individuals to chronic conditions such as periodontitis, and dental pulp inflammation. Additionally, we will briefly discuss how the oral microbiome is involved in the regulation of inflammaging. Understanding the molecular pathways of inflammaging may provide valuable insights not only into oral health but also into potential health strategies for the aging population.

Keyword

Inflammaging; Oral diseases; Inflammation; Aging; Microbiome; Oral microbiome