Perinatology.  2024 Dec;35(4):128-133. 10.14734/PN.2024.35.4.128.

The Usefulness of Gestation Corrected Hy peruricemia as Predictors of the Recurrence of Preeclampsia and Obstetric Outcomes on Subsequent Pregnancy: A Single Center Retrospective Study in South Korea

• Bang HY
• Kim JW
• Kim YH
• Choi MG
• Kim TY
• Park TH

• KMID: 2563890
• DOI: http://doi.org/10.14734/PN.2024.35.4.128

Abstract

Objective
Hyperuricemia has been described commonly in preeclamptic pregnancies, often prece ding the diagnosis of preeclampsia and historically was used as a diagnostic marker of preeclampsia. The aim of this study was to determine the usefulness of gestation corrected hyperuricemia (GCH) to predict the recurrence of preeclampsia on subsequent pregnancy.
Methods
The retrospective study of 64 women who had previous preeclampsia and checked serum uric acid was analyzed. GCH was defined as being one standard deviation above the gestation-specific mean. And we used uric acid z-scores ([serum uric acid value-gestation specific mean]/standard deviation of the population) to account for gestation-specific alterations in uric acid and tested this as a continuous variable. The relationship between GCH and recurrence of preeclampsia on subsequent pregnancy was analyzed. Obstetric outcomes were reviewed according to absence or presence of GCH. P<0.05 was considered as significant.
Results
Of 64 women, seventeen had the development of recurrent preeclampsia (26.6%). The absence or presence of GCH was not associated with the recurrence of preeclampsia on subsequent pregnancy (P=0.267). And gestation-specific uric acid z-score as a continuous variable did not show any association with the prediction of preeclampsia on subsequent pregnancy (P=0.427). GCH was associated with the small for gestational age (P=0.010).
Conclusion
GCH does not predict the recurrence of preeclampsia on subsequent pregnancy.

Keyword

Gestation corrected hyperuricemia; Pre-eclampsia; Recurrence; Predictors; Subsequent pregnancy