Korean J Obstet Gynecol.  1999 Feb;42(2):377-381.

Point Mutations in a Mitochondrial Transfer RiboNucleic Acid Gene in South Korean Women with Preeclampsia

• Ji IW
• Kim HS
• Ju KS

Abstract

OBJECTIVE
This study was performed to find out mitochondrial deoxyribonucleic acid mutations in preeclampsia because Mendelian models fail to explain all the patterns of inheritance in preeclampsia.
METHODS
Ten preeclampsia patients and two of their related family members who have the obstetric history of preeclampsia were studied. The mitochondrial transfer ribonucleic acidleu[UUR] gene was amplified using polymerase chain reaction, cut by a restriction endonuclease (Apa , and also sequenced to see the whole gene.
RESULTS
There were neither the known mutation at Nucleotide 3243 nor other mutations on the mitochondrial transfer ribonucleic acidleu[UUR] gene in these objects.
CONCLUSION
It seems that the known mutation of mitochondrial transfer ribonucleic acidleu[UUR] gene is not so frequently detected in preeclampsia of South Korean, But it could not be concluded how many South Korean women with preeclampsia have the mutation.

Keyword

Preeclampsia; South Korean; Mitochondrial transfer ribonucleic acid mutations

MeSH Terms

DNA
DNA Restriction Enzymes
Female
Humans
Point Mutation*
Polymerase Chain Reaction
Pre-Eclampsia*
RNA*
Wills
DNA
DNA Restriction Enzymes
RNA