Res Vestib Sci.
2024 Jun;23(2):37-45. 10.21790/rvs.2024.005.
Prevalence and preferred medication for vestibular migraine in Menière’s disease: a multicenter retrospective cohort study in Korea
- Lee DH
1 - Park HJ2
- Kim KS3
- Kim HJ3
- Byun JY4
- Kim MB5
- Kim M6
- Suh MW7
- Seo JH8
- Lee JD9
- Jeon EJ10
- Yoo MH11
- Hong SM12
- Hong SK13
- Lee HJ13
- Lee JW14
- Oh SJ15
- Kim HA16
- Lee H16
- Lee ES17
- Kwon EJ18
- Jeong SH18
- Choi JY19
- Kim CH1
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
- 2Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- 3Department of Otolaryngology-Head and Neck Surgery, Inha University Hospital, Inha University School of Medicine, Incheon, Korea
- 4Department of Otorhinolaryngology-Head and Neck Surgery, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea
- 5Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 6Department of Otorhinolaryngology-Head and Neck Surgery, Catholic Kwandong University International St. Mary’s Hospital, Incheon, Korea
- 7Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea
- 8Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 9Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Bucheon, Korea
- 10Department of Otolaryngology-Head and Neck Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea
- 11Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu, Korea
- 12Department of Otolaryngology-Head and Neck Surgery, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea
- 13Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- 14Department of Otorhinolaryngology, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea
- 15Department of Otorhinolaryngology, Pusan National University College of Medicine, Busan, Korea
- 16Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea
- 17Department of Neurology, Soonchunhyang University Hospital, Soonchunhyang University School of Medicine, Bucheon, Korea
- 18Department of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea
- 19Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
- KMID: 2563694
- DOI: http://doi.org/10.21790/rvs.2024.005
Abstract
Objectives
The aim of this study is to categorize headaches associated with definite Menière’s disease (MD) according to diagnostic criteria, to determine their prevalence, and to investigate the preferred medication across participating centers.
Methods
Patients diagnosed with definite MD at 17 university hospitals in otolaryngology or neurology departments in Korea between January 1, 2021 to December 31, 2021 were retrospectively included. Data on the presence of accompanying vestibular migraine (VM), migraine or non-migraine headaches, and clinical information were collected. A survey was conducted to assess preferences for treatment drugs for vertigo and headache control in MD patients with headache.
Results
A total of 435 definite MD patients were included, with a mean age of 57.0±14.9 years. Among them, 135 (31.0%) had accompanying headaches, of whom 48 (11.0% of all definite MD patients) could be diagnosed with VM. The prevalence of comorbid VM (definite and probable) was significantly higher in females (41 of 288, 14.2%) than in males (7 of 147, 4.8%) (p<0.05). There was no significant difference in the prevalence of comorbid VM between unilateral and bilateral MD patients (10.8% and 13.6%, respectively) (p > 0.05). Benzodiazepines, antihistamines, and antiemetics were mainly preferred for acute vertigo control, while nonsteroidal anti-inflammatory drugs, acetaminophen, and triptans were preferred for acute headache control, and topiramate, propranolol, and calcium channel blockers were mainly preferred for headache prevention.
Conclusions
VM is not uncommon in patients with definite MD in Korea. Further research is needed to understand the differences in headache prevalence and preferred medications across different centers.
