J Clin Neurol.  2007 Sep;3(3):121-126. 10.3988/jcn.2007.3.3.121.

Migraine Associated Vertigo

• Cha YH
• Baloh RW

• KMID: 2135489
• DOI: http://doi.org/10.3988/jcn.2007.3.3.121

Abstract

The interrelations of migraine and vertigo are complex, eluding a simple localization either centrally or peripherally. Spontaneous episodic vertigo, benign paroxysmal positional vertigo, and Meniere's disease all occur more frequently in patients with migraine than in those without. Family studies support a hereditary predisposition to migraine associated vertigo. In this review, we discuss definitions, epidemiology, associated syndromes, neurootological abnormalities, genetics and treatment for patients with migraine and vertigo.

Keyword

Migraine; Dizziness; Vertigo; BPPV; Benign recurrent vertigo; Meniere's disease; Motion sickness

MeSH Terms

Dizziness
Epidemiology
Genetics
Humans
Meniere Disease
Migraine Disorders*
Motion Sickness
Vertigo*

Reference

1. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders 2nd edition. Cephalalgia. 2004. 24:1–160.

2. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T. The interrelations of migraine, vertigo, and migrainous vertigo. Neurology. 2001. 56:436–441.

3. Crevits L, Bosman T. Migraine-related vertigo: towards a distinctive entity. Clinical Neurology and Neurosurgery. 2005. 107:82–87.

4. Brantberg K, Trees N, Baloh RW. Migraine-associated vertigo. Acta Oto-Laryngologica. 2005. 125:276–279.

5. Kayan A, Hood JD. Neuro-otological manifestations of migraine. Brain. 1984. 107:1123–1142.

6. Cutrer F, Baloh RW. Migraine-associated dizziness. Headache. 1992. 32:300–304.

7. Oh A, Lee H, Jen JC, Corona S, Jacobson KM, Baloh RW. Familial Benign Recurrent Vertigo. Am Jrnl Med Genetics. 2001. 100:287–291.

8. Neuhauser HK, von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, et al. Epidemiology of vestibular vertigo: A neurotologic survey of the general population. Neurology. 2005. 65:898–904.

9. Dieterich M, Brandt T. Episodic vertigo related to migraine (90 cases): vestibular migraine? J Neurol. 1999. 246:883–892.

10. Lipton R, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF. Migraine in the United States: Epidemiology and patterns of health care use. Neurology. 2002. 58:885–894.

11. Lipton R, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF; AMPP Advisory Group. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007. 68:343–349.

12. Neuhauser H, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, et al. Migrainous vertigo: Prevalence and impact on quality of life. Neurology. 2006. 67:1028–1033.

13. Basser L. Benign paroxysmal vertigo of childhood (a variety of vestibular neuronitis). Brain. 1964. 87:141–152.

14. Fenichel G. Migraine as a cause of benign paroxysmal vertigo of childhood. J Pediatr. 1967. 71:114–115.

15. Lanzi G, Balottin U, Fazzi E, Tagliasacchi M, Manfrin M, Mira E. Benign paroxysmal vertigo of childgood: a long-term follow-up. Cephalalgia. 1994. 14:458–460.

16. Abu-Arafeh I, Russell G. Paroxysmal vertigo as a migraine equivalent in children: a population based study. Cephalalgia. 1995. 15:22–25.

17. Marcelli V, Piazza F, Pisani F, Marciano E. Neurootological features of benign paroxysmal vertigo and benign paroxysmal positioning vertigo in children: a follow-up study. Brain Dev. 2006. 28:80–84.

18. Drigo P, Carli G, Laverda AM. Benign paroxysmal vertigo of childhood. Brain Dev. 2001. 23:38–41.

19. Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H. Migraine and Meniere's disease: Is there a link? Neurology. 2002. 59:1700–1704.

20. Hinchcliffe R. Headache and Meniere's Disease. Acta Oto-Laryngologica. 1967. 63:384–390.

21. Parker W. Meniere's Disease: Etiologic Considerations. Arch Otolaryngol Head Neck Surg. 1995. 121:377–382.

22. Rassekh C, Harker LA. The prevalence of migraine in Meniere's disease. Laryngoscope. 1992. 102:135–138.

23. Lee H, Lopez I, Ishiyama A, Baloh RW. Can Migraine Damage the Inner Ear? Arch Neurol. 2000. 57:1631–1634.

24. Cha YH, Brodsky J, Ishiyama G, Sabatti C, Baloh RW. The relevance of migraine in patients with Meniere's disease. Acta-otolaryngologica. 2007. in press.

25. Brown M. Meniere's syndrome. Arch Neurol Psychiatry. 1941. 46:561.

26. Brown M. The factor of heredity in labyrinthine deafness and paroxysmal vertigo (Meniere's syndrome). Ann Otol Rhino Laryngol. 1949. 58:665–670.

27. Bernstein J. Occurrence of episodic vertigo and hearing loss in families. Ann Otol Rhino Laryngol. 1965. 74:1011–1021.

28. Oliveira CA, Messias CI, Ferrari I. Occurrence of Familial Meniere's Syndrome and Migraine in Brasilia. Ann Otol Rhinol Laryngol. 2002. 111:229–236.

29. Sturzenegger MH, Meienberg O. Basilar artery migraine: a follow-up study of 82 cases. Headache. 1985. 25:408–415.

30. Neuhauser H, Lempert T. Vertigo and dizziness related to migraine: a diagnostic challenge. Cephalalgia. 2004. 24:83–91.

31. Baloh RW, Honrubia V, Jacobson KM. Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology. 1987. 37:371–378.

32. Epley JM. The canalith repositioning procedure: for treatment of benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 1992. 107:399–404.

33. von Brevern M, Radtke A, Clarke AH, Lempert T. Migrainous vertigo presenting as episodic positional vertigo. Neurology. 2004. 62:469–472.

34. Uneri A. Migraine and benign paroxysmal positional vertigo: an outcome study of 476 patients. ENT-Ear, Nose & Throat Journal. 2004. 83:814–815.

35. Ishiyama A, Jacobson KM, Baloh RW. Migraine and benign paroxysmal vertigo. Ann Otol Rhino Laryngol. 2000. 109:377–380.

36. von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, Lempert T, et al. Epidemiology of benign paroxysmal positional vertigo. J Neurol Neurosurg Psychiatry. 2006. Epub Nov 29.

37. Viirre E, Baloh RW. Migraine as a cause of sudden hearing loss. Headache. 1996. 36:24–28.

38. Toglia JU, Thomas D, Kuritzky A. Common migraine and vestibular function: electronystagmographic study and pathogenesis. Ann Otol. 1981. 90:267–271.

39. Bir LS, Ardic FN, Kara CO, Akalin O, Pinar HS, Celiker A. Migraine patients with or without vertigo: comparison of clinical and electronystagmographic findings. J Otolaryngology. 2003. 32:234–238.

40. Kuritzky A, Toglia UJ, Thomas DO. Vestibular function in migraine. Headache. 1981. 21:110–112.

41. von Brevern M, Zeise D, Neuhauser H, Clarke AH, Lempert T. Acute migrainous vertigo: clinical and oculographic findings. Brain. 2005. 128:365–374.

42. Cader MZ, Steckley JL, Dyment DA, McLachlan RS, Ebers GC. A genome-wide screen and linkage mapping for a large pedigree with episodic ataxia. Neurology. 2005. 65:156–158.

43. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SMG, et al. Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4. Cell. 1996. 87:543–552.

44. Browne DL, Gancher ST, Nutt JG, Brunt ER, Smith EA, Kramer P, et al. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat Genet. 1994. 8:136–140.

45. Steckley JL, Ebers GC, Cader MZ, McLachlan RS. An autosomal dominant disorder with episodic ataxia, vertigo, and tinnitus. Neurology. 2001. 1499–1502.

46. Lee H, Jen JC, Wang H, Chen Z, Mamsa H, Sabatti C, et al. A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity. Hum Mol Genet. 2006. 15:251–258.

47. Zasorin N, Baloh RW, Meyers LB. Acetazolamideresponsive episodic ataxia syndrome. Neurology. 1983. 33:1212–1214.

48. Sappey-Marinier D, Vighetto A, Peyron R, Broussolle E, Bonmartin A. Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2. Ann of Neurol. 1999. 46:256–259.

49. Waterston J. Chronic migrainous vertigo. Jrnl Clin Neurosc. 2004. 11:384–388.

50. Staab JP, Ruckenstein MJ. Which Comes First? Psychogenic Dizziness versus Otogenic Anxiety. Laryngoscope. 2003. 113:1714–1718.