Res Vestib Sci.  2015 Dec;14(4):101-109. 10.0000/rvs.2015.14.4.101.

Genetic Approach of Dizziness

Affiliations
  • 1Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. rachelbolan@hanmail.net

Abstract

Patients with recurrent vertigo/dizziness or unsteadiness are a heterogeneous group of complex disorders affecting the peripheral and central vestibular system. They represent a diagnostic challenge for the clinicians, and their genetic basis is largely not known. However, there are some cerebellar and vestibular disorders with a strong genetic background, such as episodic ataxia, spinocerebellar ataxia, vestibular migraine, Meniere's disease, and autosomal dominant nonsyndromic deafness. Furthermore, recent advances in next generation sequencing technique are increasing the number of novel genes associated with cerebellar and vestibular disorders. In this article, we have summarized clinical and molecular genetics findings in neuro-otology.

Keyword

Genetic study; Dizziness; Cerebellar ataxia; Vestibulopathy

MeSH Terms

Ataxia
Cerebellar Ataxia
Deafness
Dizziness*
Humans
Meniere Disease
Migraine Disorders
Molecular Biology
Neurotology
Spinocerebellar Ataxias
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