J Cardiovasc Interv.  2024 Jul;3(3):136-157. 10.54912/jci.2024.0009.

Bioengineering the Heart: Harnessing Biomaterials for Innovative Cardiovascular Interventions

• Jang WB
• Kwon SM

• KMID: 2561212
• DOI: http://doi.org/10.54912/jci.2024.0009

Abstract

Biomaterials play a crucial role in cardiovascular interventions, influencing biocompatibility, mechanical properties, inflammatory responses, tissue regeneration, angiogenesis, and vascular remodeling. Herein, we comprehensively explored their diverse applications in cardiovascular medicine, including medical-grade metals, polymers, ceramics, biologically derived materials, and biodegradable polymers. We explored the design principles guiding biomaterial selection, elucidated their mechanisms of action, and evaluated their clinical efficacy and safety profiles. Furthermore, we discussed recent advancements and future prospects in biomaterial-based strategies, highlighting the key challenges and opportunities for translation into clinical practice. We examined innovations in material synthesis, surface modification techniques, and fabrication methods, alongside strategies to address limitations and optimize biomaterial performance. Interdisciplinary collaborations and emerging technologies offer promising avenues for revolutionizing cardiovascular interventions and improving patient outcomes through biomaterials. This review aimed to provide clinicians, researchers, and industry stakeholders with valuable insights into the evolving landscape of biomaterial-enabled cardiovascular interventions, ultimately advancing cardiovascular medicine.

Keyword

Biomaterials; Cardiovascular interventions; Cardiovascular diseases; Biocompatible materials; Tissue regeneration; Angiogenesis