J Yeungnam Med Sci.  2024 Jan;41(1):4-12. 10.12701/jyms.2023.00010.

Octacalcium phosphate, a promising bone substitute material: a narrative review

• Kim J
• Kim S
• Song I

• KMID: 2551328
• DOI: http://doi.org/10.12701/jyms.2023.00010

Abstract

Biomaterials have been used to supplement and restore function and structure by replacing or restoring parts of damaged tissues and organs. In ancient times, the medical use of biomaterials was limited owing to infection during surgery and poor surgical techniques. However, in modern times, the medical applications of biomaterials are diversifying owing to great developments in material science and medical technology. In this paper, we introduce biomaterials, focusing on calcium phosphate ceramics, including octacalcium phosphate, which has recently attracted attention as a bone graft material.

Keyword

Bioceramics; Biomaterials; Bone substitutes; Hydroxyapatitea; Octacalcium phosphate

Figure

• 

  Fig. 1. The unit cell of the octacalcium phosphate and hydroxyapatite phase is visualized with the VESTA (Visualisation for Electronic Structural Analysis) program.

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  Fig. 2. Micrographs of octacalcium phosphate (OCP)-implanted tibial defect in the rabbit after 4 weeks and 12 weeks. (A) At 4 weeks, OCP granules (*) are visible. Active new bone formation is observed with osteoblasts (arrows) and osteocytes in lacunae (arrowheads). (B) At 12 weeks, compact bone is achieved via new bone formation with osteons (O). OCP granules are largely absorbed (hematoxylin and eosin stain).

Reference

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