J Korean Ophthalmol Soc.  2024 Nov;65(11):753-759. 10.3341/jkos.2024.65.11.753.

A Case of Paraneoplastic Autoimmune Retinopathy in a Young Man with Testicular Cancer

• Seo M
• Kim S
• Ha A
• Jeong J
• Nam KT

• KMID: 2560844
• DOI: http://doi.org/10.3341/jkos.2024.65.11.753

Abstract

Purpose
To report a case of paraneoplastic autoimmune retinopathy in a patient with a history of testicular cancer.
Case summary
A 29-year-old man presented with photopsia and floaters. Initial fundus examination revealed no abnormal findings. However, he returned 1 month later with complaints of visual field defects. Fundus examination revealed diffuse white spots in the macula and midperipheral retina and fundus autofluorescence demonstrated hyper-autofluorescence. Optical coherence tomography showed disruption of the ellipsoid zone sparing the fovea. Visual field examination revealed peripheral visual field defects and an electroretinogram showed reduced rod and cone cell responses. Considering his history of testicular cancer, serum paraneoplastic autoantibody panel testing was performed which revealed borderline levels of anti-recoverin antibody leading to a diagnosis of paraneoplastic autoimmune retinopathy. The patient was treated with oral steroids and mycophenolate mofetil for 1 year. However, there was no improvement in the subjective symptoms or ophthalmologic findings.
Conclusions
This case of paraneoplastic autoimmune retinopathy in a young man with a history of testicular cancer highlights an early clinical presentation of the disease. It is crucial to recognize that the initial clinical presentation of autoimmune retinopathy can be nonspecific.

Keyword

Autoimmune retinopathy, Cancer-associated retinopathy, Paraneoplastic retinopathy