Korean J Ophthalmol.  1999 Jun;13(1):43-48. 10.3341/kjo.1999.13.1.43.

An unusual type of cancer-associated retinopathy in a patient with ovarian cancer

• Yoon YH
• Cho EH
• Sohn J
• Thirkill C

• KMID: 1081835
• DOI: http://doi.org/10.3341/kjo.1999.13.1.43

Abstract

We studied a case of unusual retinopathy in a 35-year-old woman who presented with bilateral visual deterioration due to retinal pigmentary mottling and serous elevation in the posterior pole. Two years before, she had undergone hysterectomy and bilateral salphingo-oophorectomy for ovarian cancer. Her electroretinogram became subnormal, and her fluorescein angiogram exhibited multiple deep retinal pigment epithelial leakages and subretinal dye pooling in both eyes. Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. We report a rare variety of cancer-associated retinopathy in a patient with-ovarian cancer.

Keyword

Cancer-associated retinopathy; Paraneoplastic syndrome; Autoantibody; Ovarian cancer

MeSH Terms

Adenocarcinoma/surgery
Adenocarcinoma/pathology
Adenocarcinoma/complications*
Adult
Case Report
Diagnosis, Differential
Electroretinography
Fatal Outcome
Female
Fluorescein Angiography
Fundus Oculi
Human
Hysterectomy
Neoplasm Recurrence, Local
Ovarian Neoplasms/surgery
Ovarian Neoplasms/pathology
Ovarian Neoplasms/complications*
Paraneoplastic Syndromes/etiology*
Paraneoplastic Syndromes/diagnosis
Retinal Diseases/etiology*
Retinal Diseases/diagnosis
Support, U.S. Gov't, P.H.S.
Visual Acuity