Ann Lab Med.  2024 Nov;44(6):600-603. 10.3343/alm.2024.0043.

Fretibacterium Species to Fusobacterium periodonticum Ratio as a Potential Biomarker of Periodontitis Based on Salivary Microbiome Profiling

• Oh EJ
• Jang HH
• Park S
• Lim HP
• Yun KD
• Jang W
• Kim OS
• Park C
• Won EJ

• KMID: 2560810
• DOI: http://doi.org/10.3343/alm.2024.0043

Figure

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  Fig. 1 Salivary microbiome analysis for patients in the periodontitis and control groups. (A) The periodontitis group showed a predominance of Selenomonas and Rothia species, whereas the control group showed a predominance of Prevotella species. (B) Linear discriminant analysis (LDA) scores for differentially abundant taxa in the salivary microbiome among patients in the periodontitis group (purple) and the control group (blue). The length denotes the effect size for a given taxon. Among the taxa shown, we observed P=0.05 via Kruskal–Wallis testing and an LDA score of ≥4.0. (C) Volcano plot showing several bacterial taxa specifically associated with patients in the periodontitis or control group. (D) Ratio of Fretibacterium species to Fusobacterium periodonticum (Freti/FPO ratio) between the periodontitis and control groups. The periodontitis group showed a significantly higher Freti/FPO ratio than the control group did (median, Freti/FPO ratio, 20.16 vs. 0.28, periodontitis group vs. control group, P=0.0054). Abbreviations: Ambig, ambiguous; Uncultu, unculturable.

Reference

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