J Korean Orthop Assoc.
2024 Aug;59(4):256-276. 10.4055/jkoa.2024.59.4.256.
A Systematic Review of Prolotherapy in Musculoskeletal Disease
- Affiliations
-
- 1Hanmaeum Orthopedics Clinic, Daejeon, Korea
- 2Department of Orthopaedic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
- 3Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea
- KMID: 2558595
- DOI: http://doi.org/10.4055/jkoa.2024.59.4.256
Abstract
- Prolotherapy is a treatment that induces tissue regeneration. Traditionally, various stimulants have been used as proliferative agents, but currently, high-concentration dextrose solutions, which have relatively excellent safety and effectiveness, are mainly used. Prolotherapy induces inflammation by injecting a proliferant into a weakened ligament or tendon enthesis and uses the process of proliferation and remodeling of the damaged tissue. The effectiveness of prolotherapy for different musculoskeletal diseases has been reported, but each author reported a different protocol because the method, number of procedures, and cycle have not been standardized. Therefore, the authors conducted a systematic literature review on prolotherapy to analyze the protocols and clinical outcomes of prolotherapy. This paper presents the current knowledge on the diseases targeted by prolotherapy and the treatment methods for each disease.
