Allergy Asthma Respir Dis.
2024 Jul;12(3):102-124. 10.4168/aard.2024.12.3.102.
The Korean Academy of Asthma Allergy and Clinical Immunology guidelines for allergen immunotherapy
- Lee HY1
- Kang SY2
- Kim K3
- Kim JH4
- Ryu G5
- Min JY6
- Park KH7
- Park SY8
- Sung M9
- Lee Y10
- Yang EA11
- Jee HM12
- Ha EK13
- Shin YS10
- Lee SM2
- Chung EH14
- Choi SH15
- Koh YI16
- Kim ST17
- Nahm DH10
- Park JW7
- Shim JY18
- An YM19
- Han DH20
- Han MY12
- Lee YW
21 - Choi JH22
- for the Korean Academy of Asthma Allergy and Clinical Immunology (KAAACI) Allergen Immunotherapy and Allergen Working Group
- Affiliations
-
- 1Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 2Division of Pulmonology and Allergy, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
- 4Department of Pediatrics, Kyung Hee University Medical Center, Seoul, Korea
- 5Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 6Department of Otorhinolaryngology-Head & Neck Surgery, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
- 7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
- 8Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
- 9Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Korea
- 10Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
- 11Department of Pediatrics, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea
- 12Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea
- 13Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
- 14Department of Pediatrics, Chungnam National University School of Medicine, Daejeon, Korea
- 15Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea
- 16Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea
- 17Department of Otolaryngology-Head & Neck Surgery, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 18Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
- 19Jang’s Pediatrics, Seoul, Korea
- 20Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea
- 21Division of Allergy & Clinical Immunology, Department of Internal Medicine, Center for Health Policy Research, Catholic Kwandong University College of Medicine, International St. Mary's Hospital, Incheon, Korea
- 22Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
- KMID: 2558370
- DOI: http://doi.org/10.4168/aard.2024.12.3.102
Abstract
- Allergen immunotherapy (AIT) is a causative treatment of allergic diseases in which allergen extracts are regularly administered in a gradually escalated doses, leading to immune tolerance and consequent alleviation of allergic diseases. The need for uniform practice guidelines in AIT is continuously growing as the number of potential candidates for AIT increases and new therapeutic approaches are tried. This updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT, published in 2010, proposes an expert opinion by specialists in allergy, pediatrics, and otorhinolaryngology. This guideline deals with the basic knowledge of AIT, including mechanisms, clinical efficacy, allergen standardization, important allergens in Korea, and special consideration in pediatrics. The article also covers the methodological aspects of AIT, including patient selection, allergen selection, schedule and doses, follow-up care, efficacy measurements, and management of adverse reactions. Although this guideline suggests the optimal dosing schedule, an individualized approach and modifications are recommended considering the situation for each patient and clinic.
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