J Korean Neurol Assoc.
2024 Aug;42(3):251-254. 10.17340/jkna.2023.0062.
Acute Ischemic Stroke in a Patient with Metastatic Gastric Cancer after Ramucirumab Chemotherapy
- Affiliations
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- 1Department of Neurology, Kangbuk Samsung Hospital, Seoul, Korea
- KMID: 2558355
- DOI: http://doi.org/10.17340/jkna.2023.0062
Abstract
- Ramucirumab is a vascular endothelial growth factor (VEGF) receptor-2 inhibiting monoclonal antibody for the treatment of gastric cancer, non-small cell lung cancer, colorectal cancer, and hepatocellular carcinoma. Some VEGF inhibitors are known to increase the risk of ischemic stroke; however, their association with ramucirumab remains controversial. To the best of our knowledge, only two cases of ischemic stroke following ramucirumab treatment have been reported worldwide. We herein present the first case of acute cerebral infarction secondary to ramucirumab in Korea.
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