Yonsei Med J.  2024 Jun;65(6):348-355. 10.3349/ymj.2023.0266.

No Change in Complications Following Thyroidectomy Despite Increase in Thyroid Cancer Surgeries: A Meta-Regression Analysis

• Lee JS
• Lee JS
• Yun HJ
• Kim SM
• Chang H
• Lee YS
• Yang J
• Lee HS
• Chang HS

• KMID: 2555921
• DOI: http://doi.org/10.3349/ymj.2023.0266

Abstract

Purpose
The increase in thyroid cancer incidence has inevitably led to an increase in thyroid cancer surgeries. This meta-regression analysis aimed to determine if the rate of post-thyroidectomy complications changes by year.
Materials and Methods
PubMed and Embase databases were used to perform a systematic literature search of studies published from January 1, 2005, using the keywords “thyroidectomy” and “complication.” A meta-regression was performed for post-thyroidectomy hypocalcemia and bleeding.
Results
This meta-analysis included 25 studies involving 927751 individuals. Through the years of publications in this study, there was no significant difference in the proportion of post-thyroidectomy hypocalcemia and bleeding (p=0.9978, 0.6393).
Conclusion
Although the number of thyroid surgeries has recently increased, the incidence of post-thyroidectomy hypocalcemia and bleeding did not significantly increase.

Keyword

Thyroidectomy; complication; meta-analysis; meta-regression; PubMed; incidence