Nat Prod Sci.  2024 Mar;30(1):1-7. 10.20307/nps.2024.30.1.1.

Benzoquinone Derivatives with Neuroprotective Activities from Lysimachia vulgaris L.

• Park CW
• Lee J
• Pel P
• Lee SE
• Chin YW

• KMID: 2555439
• DOI: http://doi.org/10.20307/nps.2024.30.1.1

Abstract

The ethyl acetate-soluble fraction of Lysimachia vulgaris , which was found to suppress β-amyloid production in Aβ-treated PC12 cells, was purified using various column chromatographies, resulting in the isolation of four known compounds, 2,4,6-triphenylhex-1-ene (1), pinoresinol (2), monomethyl embelin (3), and 2-hydroxy-5-methoxy-3-tridecyclohexa-2,5-diene-1,4-dione (4). The isolated compounds 3 and 4 downregulated P-tau production in Aβ-treated SH-SY5Y cells and demonstrated the inhibitory activities against NO production in lipopolysaccharide (LPS)-treated BV2 cells.

Keyword

Lysimachia vulgaris; Benzoquinones; β-Amyloid (Aβ) production; P-tau production; NO production