- Chemical Constituents from Agrimonia pilosa with Inhibitory Activity against Interleukin 1β Production via NLRP3 and NLRC4 Inflammasomes
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Nhoek P, Chae HS, An CY, Pel P, Kim YM, Chin YW
- KMID: 2524102
- Nat Prod Sci.
- 2021 Dec;27(4):228-233.
- doi: 10.20307/nps.2021.27.4.228
Bioactivity-guided fractionation by preliminary screening using interleukin-1β production in lipopolysaccharides (LPS)-induced J774A.1 cell line led to the isolation of fourteen structures including chromone, isocoumarins, flavanoids, and triterpenes from the aerial... -
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- Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis
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Park JM, Pel P, Chin YW, Lee MY
- KMID: 2409611
- Nat Prod Sci.
- 2018 Mar;24(1):59-65.
- doi: 10.20307/nps.2018.24.1.59
An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically... -
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