J Korean Med Sci.  2024 Apr;39(13):e120. 10.3346/jkms.2024.39.e120.

Prevalence and Associated Factors of Depression and Anxiety Among Healthcare Workers During the Coronavirus Disease 2019 Pandemic: A Nationwide Study in Korea

Affiliations
  • 1Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Korea
  • 2Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
  • 3Department of Psychiatry, Kyungpook National University Children's Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
  • 4Division of Infectious Diseases, Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea
  • 5Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 6Department of Emergency Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
  • 7Division of Infectious Diseases, Kyungpook National University Chilgok Hospital, Daegu, Korea
  • 8Hospital Infection Control Team, Daegu Medical Center, Daegu, Korea
  • 9Department of Psychiatry, National Medical Center, Seoul, Korea
  • 10Division of Infectious Disease, Department of Internal Medicine, National Medical Center, Seoul, Korea
  • 11Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
  • 12Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
  • 13Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
  • 14Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
  • 15Division of Infectious Diseases, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 16Department of Internal Medicine, Konyang University Hospital, Daejeon, Korea
  • 17Division of Respiratory Diseases, Department of Internal Medicine, Masan Medical Center, Changwon, Korea
  • 18Department of Internal Medicine, Andong Medical Center, Andong, Korea
  • 19Division of Infectious Diseases, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea
  • 20Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea
  • 21Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
  • 22Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Korea
  • 23Department of Counseling Psychology, Hankuk University of Foreign Studies, Seoul, Korea

Abstract

Background
A healthcare system’s collapse due to a pandemic, such as the coronavirus disease 2019 (COVID-19), can expose healthcare workers (HCWs) to various mental health problems. This study aimed to investigate the impact of the COVID-19 pandemic on the depression and anxiety of HCWs.
Methods
A nationwide questionnaire-based survey was conducted on HCWs who worked in healthcare facilities and public health centers in Korea in December 2020. Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) were used to measure depression and anxiety. To investigate factors associated with depression and anxiety, stepwise multiple logistic regression analysis was performed.
Results
A total of 1,425 participating HCWs were included. The mean depression score (PHQ-9) of HCWs before and after COVID-19 increased from 2.37 to 5.39, and the mean anxiety score (GAD-7) increased from 1.41 to 3.41. The proportion of HCWs with moderate to severe depression (PHQ-9 ≥ 10) increased from 3.8% before COVID-19 to 19.5% after COVID-19, whereas that of HCWs with moderate to severe anxiety (GAD-7 ≥ 10) increased from 2.0% to 10.1%. In our study, insomnia, chronic fatigue symptoms and physical symptoms after COVID-19, anxiety score (GAD-7) after COVID-19, living alone, and exhaustion were positively correlated with depression. Furthermore, post-traumatic stress symptoms, stress score (Global Assessment of Recent Stress), depression score (PHQ-9) after COVID-19, and exhaustion were positively correlated with anxiety.
Conclusion
In Korea, during the COVID-19 pandemic, HCWs commonly suffered from mental health problems, including depression and anxiety. Regularly checking the physical and mental health problems of HCWs during the COVID-19 pandemic is crucial, and social support and strategy are needed to reduce the heavy workload and psychological distress of HCWs.

Keyword

Depression; Anxiety; COVID-19; Pandemic; Healthcare Worker

Reference

1. Goulia P, Mantas C, Dimitroula D, Mantis D, Hyphantis T. General hospital staff worries, perceived sufficiency of information and associated psychological distress during the A/H1N1 influenza pandemic. BMC Infect Dis. 2010; 10(1):322. PMID: 21062471.
2. Lin CY, Peng YC, Wu YH, Chang J, Chan CH, Yang DY. The psychological effect of severe acute respiratory syndrome on emergency department staff. Emerg Med J. 2007; 24(1):12–17. PMID: 17183035.
3. Straus SE, Wilson K, Rambaldini G, Rath D, Lin Y, Gold WL, et al. Severe acute respiratory syndrome and its impact on professionalism: qualitative study of physicians’ behaviour during an emerging healthcare crisis. BMJ. 2004; 329(7457):83. PMID: 15175231.
4. Chen X, Arber A, Gao J, Zhang L, Ji M, Wang D, et al. The mental health status among nurses from low-risk areas under normalized COVID-19 pandemic prevention and control in China: a cross-sectional study. Int J Ment Health Nurs. 2021; 30(4):975–987. PMID: 33811426.
5. Maciaszek J, Ciulkowicz M, Misiak B, Szczesniak D, Luc D, Wieczorek T, et al. Mental health of medical and non-medical professionals during the peak of the COVID-19 pandemic: a cross-sectional nationwide study. J Clin Med. 2020; 9(8):2527. PMID: 32764509.
6. Williamson V, Murphy D, Greenberg N. COVID-19 and experiences of moral injury in front-line key workers. Occup Med (Lond). 2020; 70(5):317–319. PMID: 32239155.
7. Neto MLR, Almeida HG, Esmeraldo JD, Nobre CB, Pinheiro WR, de Oliveira CRT, et al. When health professionals look death in the eye: the mental health of professionals who deal daily with the 2019 coronavirus outbreak. Psychiatry Res. 2020; 288:112972. PMID: 32302817.
8. Kliszcz J, Nowicka-Sauer K, Trzeciak B, Sadowska A. The level of anxiety, depression and aggression in nurses and their life and job satisfaction. Med Pr. 2004; 55(6):461–468. PMID: 15887514.
9. Ghawadra SF, Lim Abdullah K, Choo WY, Danaee M, Phang CK. The effect of mindfulness-based training on stress, anxiety, depression and job satisfaction among ward nurses: a randomized control trial. J Nurs Manag. 2020; 28(5):1088–1097. PMID: 32432795.
10. Kroenke K, Spitzer RL, Williams JB. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med. 2002; 64(2):258–266. PMID: 11914441.
11. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989; 46(10):1121–1123. PMID: 2803071.
12. Spitzer RL, Kroenke K, Williams JB. Primary Care Evaluation of Mental Disorders. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999; 282(18):1737–1744. PMID: 10568646.
13. Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006; 166(10):1092–1097. PMID: 16717171.
14. Prins A, Bovin MJ, Smolenski DJ, Marx BP, Kimerling R, Jenkins-Guarnieri MA, et al. The primary care PTSD screen for DSM-5 (PC-PTSD-5): development and evaluation within a veteran primary care sample. J Gen Intern Med. 2016; 31(10):1206–1211. PMID: 27170304.
15. Bastien CH, Vallières A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001; 2(4):297–307. PMID: 11438246.
16. Peterson U, Demerouti E, Bergström G, Åsberg M, Nygren Å. Work characteristics and sickness absence in burnout and nonburnout groups: a study of Swedish health care workers. Int J Stress Manag. 2008; 15(2):153–172.
17. Koh KB, Park JK. Validity and reliability of the Korean version of the global assessment of recent stress scale. Korean J Psychosom Med. 2000; 8(2):201–211.
18. In : Kim SY, Min JA, Chae JH, Kim M, Kim JH, editors. Development and validation of the Positive Resources Test (POREST). Proceeding of the Korean Psychological Association Conference; 2013 Aug 22–24; Daejeon, Korea. Seoul: Korean Psychological Association;2013. p. 143.
19. Lyoo YC, Ju S, Kim E, Kim JE, Lee JH. The patient health questionnaire-15 and its abbreviated version as screening tools for depression in Korean college and graduate students. Compr Psychiatry. 2014; 55(3):743–748. PMID: 24342054.
20. Chung KI, Song CH. Clinical usefulness of fatigue severity scale for patients with fatigue, and anxiety or depression. Korean J Psychosom Med. 2001; 9(2):164–173.
21. Park SJ, Choi HR, Choi JH, Kim K, Hong JP. Reliability and validity of the Korean version of the Patient Health Questionnaire-9 (PHQ-9). Anxiety Mood. 2010; 6(2):119–124.
22. Lee SH, Shin C, Kim H, Jeon SW, Yoon HK, Ko YH, et al. Validation of the Korean version of the generalized anxiety disorder 7 self-rating scale. Asia-Pac Psychiatry. 2022; 14(1):e12421. PMID: 32893471.
23. Jung YE, Kim D, Kim WH, Roh D, Chae JH, Park JE. A brief screening tool for PTSD: validation of the Korean version of the primary care PTSD screen for DSM-5 (K-PC-PTSD-5). J Korean Med Sci. 2018; 33(52):e338. PMID: 30584416.
24. Cho YW, Song ML, Morin CM. Validation of a Korean version of the insomnia severity index. J Clin Neurol. 2014; 10(3):210–215. PMID: 25045373.
25. Seo YE, Kim HC, Yoo SY, Lee KU, Lee HW, Lee SH. Factors associated with burnout among healthcare workers during an outbreak of MERS. Psychiatry Investig. 2020; 17(7):674–680.
26. Huh HJ, Kim KH, Lee HK, Jeong BR, Hwang JH, Chae JH. Perceived stress, positive resources and their interactions as possible related factors for depressive symptoms. Psychiatry Investig. 2021; 18(1):59–68.
27. Choi EPH, Hui BPH, Wan EYF. Depression and anxiety in Hong Kong during COVID-19. Int J Environ Res Public Health. 2020; 17(10):3740. PMID: 32466251.
28. Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou P. Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: a systematic review and meta-analysis. Brain Behav Immun. 2020; 88:901–907. PMID: 32437915.
29. Shin C, Kim Y, Park S, Yoon S, Ko YH, Kim YK, et al. Prevalence and associated factors of depression in general population of Korea: results from the Korea National Health and Nutrition Examination Survey, 2014. J Korean Med Sci. 2017; 32(11):1861–1869. PMID: 28960042.
30. Kocalevent RD, Hinz A, Brähler E. Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry. 2013; 35(5):551–555. PMID: 23664569.
31. Yu X, Tam WW, Wong PT, Lam TH, Stewart SM. The Patient Health Questionnaire-9 for measuring depressive symptoms among the general population in Hong Kong. Compr Psychiatry. 2012; 53(1):95–102. PMID: 21193179.
32. The survey of mental disorders in Korea 2016. Updated 2017. Accessed August 2, 2023. https://www.mohw.go.kr/react/gm/sgm0704vw.jsp?PAR_MENU_ID=13&MENU_ID=13040801&page=1&CONT_SEQ=357654&PAR_CONT_SEQ=355847 .
33. Le Thi Ngoc A, Dang Van C, Nguyen Thanh P, Lewycka S, Van Nuil JI. Depression, anxiety, and stress among frontline health workers during the second wave of COVID-19 in southern Vietnam: a cross-sectional survey. PLOS Glob Public Health. 2022; 2(9):e0000823. PMID: 36962750.
34. Garabiles MR, Lao CK, Yip P, Chan EW, Mordeno I, Hall BJ. Psychometric validation of PHQ–9 and GAD–7 in Filipino migrant domestic workers in Macao (SAR), China. J Pers Assess. 2020; 102(6):833–844. PMID: 31361153.
35. Alloy LB, Kelly KA, Mineka S, Clements CM. Comorbidity of anxiety and depressive disorders: a helplessness-hopelessness perspective. Maser JD, Cloninger CR, editors. Comorbidity of Mood and Anxiety Disorders. Virginia, WV, USA: American Psychiatric Association;1990. p. 499–543.
36. Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, et al. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open. 2020; 3(3):e203976. PMID: 32202646.
37. Cai Z, Cui Q, Liu Z, Li J, Gong X, Liu J, et al. Nurses endured high risks of psychological problems under the epidemic of COVID-19 in a longitudinal study in Wuhan China. J Psychiatr Res. 2020; 131:132–137. PMID: 32971356.
38. Cag Y, Erdem H, Gormez A, Ankarali H, Hargreaves S, Ferreira-Coimbra J, et al. Anxiety among front-line health-care workers supporting patients with COVID-19: a global survey. Gen Hosp Psychiatry. 2021; 68:90–96. PMID: 33418193.
39. Que J, Shi L, Deng J, Liu J, Zhang L, Wu S, et al. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatr. 2020; 33(3):e100259. PMID: 32596640.
40. Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C, Voderholzer U, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011; 135(1-3):10–19. PMID: 21300408.
41. Li L, Wu C, Gan Y, Qu X, Lu Z. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies. BMC Psychiatry. 2016; 16(1):375. PMID: 27816065.
42. Killgore WD, Cloonan SA, Taylor EC, Fernandez F, Grandner MA, Dailey NS. Suicidal ideation during the COVID-19 pandemic: the role of insomnia. Psychiatry Res. 2020; 290:113134. PMID: 32505030.
43. McCall WV, Blocker JN, D’Agostino R Jr, Kimball J, Boggs N, Lasater B, et al. Insomnia severity is an indicator of suicidal ideation during a depression clinical trial. Sleep Med. 2010; 11(9):822–827. PMID: 20478741.
44. Neckelmann D, Mykletun A, Dahl AA. Chronic insomnia as a risk factor for developing anxiety and depression. Sleep. 2007; 30(7):873–880. PMID: 17682658.
45. Chu C, Hom MA, Rogers ML, Ringer FB, Hames JL, Suh S, et al. Is insomnia lonely? Exploring thwarted belongingness as an explanatory link between insomnia and suicidal ideation in a sample of South Korean university students. J Clin Sleep Med. 2016; 12(5):647–652. PMID: 26857060.
46. Nadorff MR, Fiske A, Sperry JA, Petts R, Gregg JJ. Insomnia symptoms, nightmares, and suicidal ideation in older adults. J Gerontol B Psychol Sci Soc Sci. 2013; 68(2):145–152. PMID: 22929392.
47. Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, et al. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry. 2020; 11:306. PMID: 32346373.
48. Ahmadi M, Choobineh A, Mousavizadeh A, Daneshmandi H. Physical and psychological workloads and their association with occupational fatigue among hospital service personnel. BMC Health Serv Res. 2022; 22(1):1150. PMID: 36096773.
49. Ulfa M, Azuma M, Steiner A. Burnout status of healthcare workers in the world during the peak period of the COVID-19 pandemic. Front Psychol. 2022; 13:952783. PMID: 36211838.
50. Hwang S, Kwon KT, Lee SH, Kim SW, Chang HH, Kim Y, et al. Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea. Sci Rep. 2023; 13(1):3360. PMID: 36849638.
51. Manookian A, Dehghan Nayeri N, Shahmari M. Physical problems of prolonged use of personal protective equipment during the COVID-19 pandemic: a scoping review. Nurs Forum. 2022; 57(5):874–884. PMID: 35575417.
52. Jin H, Liu L, Li Y, Chen C, Fu Q. Influence of different protection levels of PPE on nurses’ physical fatigue during the COVID-19 pandemic. Work. 2022; 72(4):1143–1152. PMID: 35723164.
53. Jang HJ, Kim O, Kim S, Kim MS, Choi JA, Kim B, et al. Factors affecting physical and mental fatigue among female hospital nurses: the Korea Nurses’ Health Study. Healthcare (Basel). 2021; 9(2):201. PMID: 33668525.
54. Guha M. Diagnostic and statistical manual of mental disorders: DSM-5. Ref Rev. 2014; 28(3):36–37.
55. Ginzburg K, Ein-Dor T, Solomon Z. Comorbidity of posttraumatic stress disorder, anxiety and depression: a 20-year longitudinal study of war veterans. J Affect Disord. 2010; 123(1-3):249–257. PMID: 19765828.
56. Spinhoven P, Penninx BW, van Hemert AM, de Rooij M, Elzinga BM. Comorbidity of PTSD in anxiety and depressive disorders: prevalence and shared risk factors. Child Abuse Negl. 2014; 38(8):1320–1330. PMID: 24629482.
57. Lee SM, Kang WS, Cho AR, Kim T, Park JK. Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients. Compr Psychiatry. 2018; 87:123–127. PMID: 30343247.
58. d’Ettorre G, Ceccarelli G, Santinelli L, Vassalini P, Innocenti GP, Alessandri F, et al. Post-traumatic stress symptoms in healthcare workers dealing with the COVID-19 pandemic: a systematic review. Int J Environ Res Public Health. 2021; 18(2):601. PMID: 33445712.
59. Norman SB, Feingold JH, Kaye-Kauderer H, Kaplan CA, Hurtado A, Kachadourian L, et al. Moral distress in frontline healthcare workers in the initial epicenter of the COVID-19 pandemic in the United States: relationship to PTSD symptoms, burnout, and psychosocial functioning. Depress Anxiety. 2021; 38(10):1007–1017. PMID: 34293236.
60. Eggert L, Schröder J, Lotzin A. Living alone is related to depressive symptoms during the COVID-19 pandemic. J Public Health. 2023.
61. Liu CH, Zhang E, Wong GTF, Hyun S, Hahm HC. Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: clinical implications for U.S. young adult mental health. Psychiatry Res. 2020; 290:113172. PMID: 32512357.
62. Liu Y, Chen H, Zhang N, Wang X, Fan Q, Zhang Y, et al. Anxiety and depression symptoms of medical staff under COVID-19 epidemic in China. J Affect Disord. 2021; 278:144–148. PMID: 32961409.
63. Schug C, Morawa E, Geiser F, Hiebel N, Beschoner P, Jerg-Bretzke L, et al. Social support and optimism as protective factors for mental health among 7765 healthcare workers in Germany during the COVID-19 pandemic: results of the VOICE study. Int J Environ Res Public Health. 2021; 18(7):3827. PMID: 33917493.
64. Krifa I, van Zyl LE, Braham A, Ben Nasr S, Shankland R. Mental health during COVID-19 pandemic: the role of optimism and emotional regulation. Int J Environ Res Public Health. 2022; 19(3):1413. PMID: 35162435.
65. Carver CS, Scheier MF, Segerstrom SC. Optimism. Clin Psychol Rev. 2010; 30(7):879–889. PMID: 20170998.
66. Zhang H, Zhao Y, Zou P, Liu Y, Lin S, Ye Z, et al. The relationship between autonomy, optimism, work engagement and organisational citizenship behaviour among nurses fighting COVID-19 in Wuhan: a serial multiple mediation. BMJ Open. 2020; 10(9):e039711.
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