Korean J Dermatol.  2024 Mar;62(3):172-176.

Spontaneous Improvement of Eosinophilic Dermatosis of Hematologic Malignancy Concurrent with Follicular Lymphoma after Rituximab and Bendamustine Therapy

• Park KD
• Yoo DW
• Kwon HJ
• Yi JH
• Kim HJ
• Kim KH
• Yoon JH

Abstract

Eosinophilic dermatosis of hematological malignancy (EDHM) is a rare condition associated with various hematologic malignancies, characterized by pruritic skin eruptions. We present a case of a 66-year-old woman with follicular lymphoma who developed urticarial and vesicular lesions indicative of EDHM following chemotherapy. The diagnosis was confirmed through histological analysis, revealing eosinophilic infiltration. Treatment included additional chemotherapy sessions and topical corticosteroids, resulting in complete resolution of skin lesions and lymphoma. EDHM requires careful differentiation based on clinical and histological findings. The pathogenesis remains unclear, but addressing underlying hematologic malignancies appears crucial in management. Early recognition of EDHM is essential for appropriate intervention due to its limited therapeutic options.

Keyword

Bendamustine hydrochloride; Eosinophilic dermatosis of hematologic malignancy; Follicular lymphoma; Rituximab